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The Effect of Pregabalin on Preoperative Anxiety and Postoperative Pain in Patients Undergoing Percutaneous Nephrolithotomy: A Randomized Controlled Trial Publisher



Djafari AA1 ; Khorram AA2 ; Hojjati SA3 ; Fayaz M4 ; Eslami AH2 ; Garousi M5 ; Faraji S6 ; Aghabeiki E7
Authors
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Authors Affiliations
  1. 1. Clinical Research Development Unit of Shohada-e Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Urology Department, Shohada-e Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. ECO College of Insurance, Allameh Tabataba’i University, Tehran, Iran
  5. 5. Radiation Oncology Department, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Shahid Akbarabadi Clinical Research Development Unit (ShACRDU), School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Medical Journal of the Islamic Republic of Iran Published:2025


Abstract

Background: Percutaneous nephrolithotomy (PCNL) is the preferred surgical technique for treating kidney stones. Preoperative anxiety is a common psychiatric symptom experienced by many patients undergoing surgery. We aimed to evaluate the effects of pregabalin administration on preoperative anxiety and postoperative pain in patients undergoing PCNL. Methods: This randomized controlled trial included 104 patients who were scheduled for PCNL surgery and were randomly assigned to 1 of the 4 groups: placebo, 75 mg of pregabalin, 150 mg of pregabalin, or 300 mg of pregabalin. The anxiety level was measured using the Hamilton Rating Scale for Anxiety (HRSA), and the postoperative pain was assessed using the visual analog scale (VAS). Methods such as the Wilcoxon Signed Ranks Test was used for the before-after test and the Kruskal Wallis Test was used for between-group time comparisons. The generalized estimation equation (GEE) and Poisson log-linear were used for the link function. Results: After comparing the different doses of pregabalin to the placebo, no statistically significant relationships were detected (P=0.931 and P=0.886, respectively). In the group-time study of these patients, the pain level in all 4 groups decreased with time. This decrease in pain was statistically significant for most of the groups (P<0.05). Conclusion: Administering pregabalin before PCNL surgery does not significantly reduce anxiety in patients before the procedure. However, preoperative administration of pregabalin has been found to be beneficial for alleviating postoperative pain in patients who have undergone PCNL surgery, with the optimal dosage of 75 mg pregabalin. © (2025), (Iran University of Medical Sciences). All rights reserved.
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