Potential Nephroprotective Effects of Resveratrol in Drug Induced Nephrotoxicity: A Narrative Review of Safety and Efficacy Data Publisher



Shahbazi F^{1, 2} ; Farvadi F³ ; Dashtikhavidaki S⁴ ; Ataei S⁵ ; Shojaei L^{1, 2} Show Affiliations
Source: Advances in Traditional Medicine Published:2020

Abstract

Drug induced nephrotoxicity commonly occurs in hospitalized patients and sometimes may complicate treatment outcome, especially in critically ill patients. No universal prophylactic agent is available yet to protect against drug related nephrotoxicity. Many modalities have been applied with different successes. Polyphenolic compounds such as resveratrol have been used both in-vitro and in vivo to prevent drug induced nephrotoxicity. Resveratrol have several antioxidant, antiplatelet and nitric oxide releasing properties in preclinical studies. In this review, we discuss recent studies that evaluated resveratrol protective effects, the mechanism of action and safety issues on drug induced nephrotoxicity. © 2020, Institute of Korean Medicine, Kyung Hee University.