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Smart Wearable Nanopaper Patch for Continuous Multiplexed Optical Monitoring of Sweat Parameters Publisher



Sharifi AR1 ; Ardalan S1 ; Tabatabaee RS1 ; Soleimani Gorgani S2 ; Yousefi H3 ; Omidfar K2 ; Kiani MA1 ; Dincer C4, 5 ; Naghdi T1, 5 ; Golmohammadi H1, 5
Authors
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Authors Affiliations
  1. 1. Nanosensor Bioplatforms Laboratory, Chemistry and Chemical Engineering Research Center of Iran, Tehran, 14335-186, Iran
  2. 2. Biosensor Research Center, Endocrinology and Metabolism Cellular and Molecular Sciences Institute, Tehran University of Medical Sciences, Tehran, 14395/1179, Iran
  3. 3. Laboratory of Sustainable Nanomaterials, Department of Wood Engineering and Technology, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, 4913815739, Iran
  4. 4. FIT Freiburg Centre for Interactive Materials and Bioinspired Technology, University of Freiburg, Freiburg, 79110, Germany
  5. 5. IMTEK − Department of Microsystems Engineering, University of Freiburg, Freiburg, 79110, Germany

Source: Analytical Chemistry Published:2023


Abstract

Notwithstanding the substantial progress in optical wearable sensing devices, developing wearable optical sensors for simultaneous, real-time, and continuous monitoring of multiple biomarkers is still an important, yet unmet, demand. Aiming to address this need, we introduced for the first time a smart wearable optical sensor (SWOS) platform combining a multiplexed sweat sensor sticker with its IoT-enabled readout module. We employed our SWOS system for on-body continuous, real-time, and simultaneous fluorimetric monitoring of sweat volume (physical parameter) and pH (chemical marker). Herein, a variation in moisture (5-45 μL) or pH (4.0-7.0) causes a color/fluorescence change in the copper chloride/fluorescein immobilized within a transparent chitin nanopaper (ChNP) in a selective and reversible manner. Human experiments conducted on athletic volunteers during exercise confirm that our developed SWOS platform can be efficiently exploited for smart perspiration analysis toward personalized health monitoring. Moreover, our system can be further extended for the continuous and real-time multiplexed monitoring of various biomarkers (metabolites, proteins, or drugs) of sweat or other biofluids (for example, analyzing exhaled breath by integrating onto a facemask). © 2023 American Chemical Society.