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Deep Adaptive Transfer Learning for Site-Specific Pet Attenuation and Scatter Correction From Multi-National/Institutional Datasets Publisher



Shiri I1 ; Salimi Y1 ; Maghsudi M2 ; Hajianfar G2 ; Jafari E3 ; Samimi R4 ; Khateri M5 ; Sheikhzadeh P6 ; Geramifar P7 ; Dadgar H8 ; Rajabi AB2 ; Assadi M3 ; Benard F9, 10 ; Uribe C9, 10 Show All Authors
Authors
  1. Shiri I1
  2. Salimi Y1
  3. Maghsudi M2
  4. Hajianfar G2
  5. Jafari E3
  6. Samimi R4
  7. Khateri M5
  8. Sheikhzadeh P6
  9. Geramifar P7
  10. Dadgar H8
  11. Rajabi AB2
  12. Assadi M3
  13. Benard F9, 10
  14. Uribe C9, 10
  15. Rahmim A9, 10
  16. Zaidi H1
Show Affiliations
Authors Affiliations
  1. 1. Geneva University Hospital, Division of Nuclear Medicine and Molecular Imaging, Geneva, 1211, Switzerland
  2. 2. Iran University of Medical Sciences, Rajaie Cardiovascular Medical and Research Center, Tehran, Iran
  3. 3. Bushehr Medical University Hospital, Department of Molecular Imaging and Radionuclide Therapy, Bushehr, Iran
  4. 4. Shahid Beheshti University, Department of Medical Radiation Engineering, Tehran, Iran
  5. 5. Islamic Azad University, Science and Research Branch, Department of Medical Radiation Engineering, Iran
  6. 6. Tehran University of Medical Sciences, Imam Khomeini Hospital Complex, Department of Nuclear Medicine, Tehran, Iran
  7. 7. Tehran University of Medical Sciences, Research Center for Nuclear Medicine, Shariati Hospital, Tehran, Iran
  8. 8. Imam Reza International University, Cancer Research Center, Razavi Hospital, Mashhad, Iran
  9. 9. The Department of Radiology, University of British Columbia, Canada
  10. 10. Bc Cancer, Vancouver, Canada

Source: 2022 IEEE NSS/MIC RTSD - IEEE Nuclear Science Symposium# Medical Imaging Conference and Room Temperature Semiconductor Detector Conference Published:2022


Abstract

Attenuation and scatter correction (ASC) must be performed for quantitative PET imaging. ASC is a challenging task in PET-only and PET/MRI systems. Different single-center or scanner-specific studies have been performed by using deep learning (DL) algorithms. However, the generalizability of these models is limited. In addition, providing large datasets for data-hungry DL models is a bottleneck. However, a universal model may not perform very well for each center because of high variability across different centers in scanners and image acquisition and reconstruction protocols. Therefore, we aimed to apply deep transfer learning for site-specific PET ASC utilizing a multi-center dataset. Altogether, 43068Ga-PSMA/DOTA PET/CT images from three countries (Switzerland, Iran, and Canada), including eight different centers, were enrolled in this study. In all centers, PET images were corrected by using CT images for ASC. In addition, we implemented a deep supervised U-Net network architecture, U2Net, as the core DL model. Different scenarios were investigated in this study, including (i) training and testing models for each center separately: center-based (CeBa); (ii) training and testing models using the entirety of the dataset: centralized (CeZe); i.e., entire data pooled together; and (iii) transfer learning (TrLe) where training was performed using pooled data to one server using entire dataset and then TrLe were performed for each center separately to build site-specific models for each center. In terms of absolute relative error (ARE%), CeBa, CeZe, and TrLe achieved 36 ± 13 (CI95%: 33 to 39), 31 ± 34 (CI95%: 24 to 38).Furthermore, using TrLe outperformed the centralized and center-based models in terms of accurate ASC image generation. © 2022 IEEE.
1. Deep Vision Transformers for Prognostic Modeling in Covid-19 Patients Using Large Multi-Institutional Chest Ct Dataset, 2022 IEEE NSS/MIC RTSD - IEEE Nuclear Science Symposium# Medical Imaging Conference and Room Temperature Semiconductor Detector Conference (2022)
2. Deep Active Learning Model for Adaptive Pet Attenuation and Scatter Correction in Multi-Centric Studies, 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference Record# NSS/MIC 2021 and 28th International Symposium on Room-Temperature Semiconductor Detectors# RTSD 2022 (2021)
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