Ugi Four-Multicomponent Reaction Based Synthesis, in Vitro, and in Silico Enzymatic Evaluations of New Pyrazino[1,2-A]Indole-1,4-Dione-Indole-2-Phenylacetamides As Potent Inhibitors Against Α-Glucosidase and Α-Amylase

Ugi Four-Multicomponent Reaction Based Synthesis, in Vitro, and in Silico Enzymatic Evaluations of New Pyrazino[1,2-A]Indole-1,4-Dione-Indole-2-Phenylacetamides As Potent Inhibitors Against Α-Glucosidase and Α-Amylase Publisher Pubmed

Ahmadi Shourkaei F¹ ; Rashidi Ranjbar P¹ ; Taslimi P² ; Mahdavi M³

Show Affiliations

1. School of Chemistry, College of Science, University of Tehran, Tehran, Iran
2. Department of Biotechnology, Faculty of Science, Bartin University, Bartin, Turkey
3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Chemistry and Biodiversity Published:2024

Abstract

In this work, synthesis and evaluation of pyrazino[1,2-a]indole-1,4-dione-indole-2-phenylacetamides 6 a–k as new synthetic anti-diabetes agents were presented. These compounds were synthesized by a four-component Ugi reaction without metal catalyst. All synthesized compounds were evaluated against α-glucosidase and α-amylase as two important targets in the treatment of diabetes. Approximately, all new compounds 6 a–k were more potent than positive control acarbose against these studied enzymes. The obtained potent compounds against the target enzymes were docked in the active site of the related enzyme. Docking study showed that our new potent compounds as well interacted with key residues of the target enzyme. © 2023 Wiley-VHCA AG, Zurich, Switzerland.

Style	Citing Format
MLA	Ahmadi Shourkaei F, et al.. "Ugi Four-Multicomponent Reaction Based Synthesis, in Vitro, and in Silico Enzymatic Evaluations of New Pyrazino[1,2-A]Indole-1,4-Dione-Indole-2-Phenylacetamides As Potent Inhibitors Against Α-Glucosidase and Α-Amylase." Chemistry and Biodiversity, vol. 21, no. 2, 2024, pp. -.
APA	Ahmadi Shourkaei F, Rashidi Ranjbar P, Taslimi P, Mahdavi M (2024). Ugi Four-Multicomponent Reaction Based Synthesis, in Vitro, and in Silico Enzymatic Evaluations of New Pyrazino[1,2-A]Indole-1,4-Dione-Indole-2-Phenylacetamides As Potent Inhibitors Against Α-Glucosidase and Α-Amylase. Chemistry and Biodiversity, 21(2), -.
Chicago	Ahmadi Shourkaei F, Rashidi Ranjbar P, Taslimi P, Mahdavi M. "Ugi Four-Multicomponent Reaction Based Synthesis, in Vitro, and in Silico Enzymatic Evaluations of New Pyrazino[1,2-A]Indole-1,4-Dione-Indole-2-Phenylacetamides As Potent Inhibitors Against Α-Glucosidase and Α-Amylase." Chemistry and Biodiversity 21, no. 2 (2024): -.
Harvard	Ahmadi Shourkaei F et al. (2024) 'Ugi Four-Multicomponent Reaction Based Synthesis, in Vitro, and in Silico Enzymatic Evaluations of New Pyrazino[1,2-A]Indole-1,4-Dione-Indole-2-Phenylacetamides As Potent Inhibitors Against Α-Glucosidase and Α-Amylase', Chemistry and Biodiversity, 21(2), pp. -.
Vancouver	Ahmadi Shourkaei F, Rashidi Ranjbar P, Taslimi P, Mahdavi M. Ugi Four-Multicomponent Reaction Based Synthesis, in Vitro, and in Silico Enzymatic Evaluations of New Pyrazino[1,2-A]Indole-1,4-Dione-Indole-2-Phenylacetamides As Potent Inhibitors Against Α-Glucosidase and Α-Amylase. Chemistry and Biodiversity. 2024;21(2):-.
BibTex	@article{ author = {Ahmadi Shourkaei F and Rashidi Ranjbar P and Taslimi P and Mahdavi M}, title = {Ugi Four-Multicomponent Reaction Based Synthesis, in Vitro, and in Silico Enzymatic Evaluations of New Pyrazino[1,2-A]Indole-1,4-Dione-Indole-2-Phenylacetamides As Potent Inhibitors Against Α-Glucosidase and Α-Amylase}, journal = {Chemistry and Biodiversity}, volume = {21}, number = {2}, pages = {-}, year = {2024} }
RIS	TY - JOUR AU - Ahmadi Shourkaei F AU - Rashidi Ranjbar P AU - Taslimi P AU - Mahdavi M TI - Ugi Four-Multicomponent Reaction Based Synthesis, in Vitro, and in Silico Enzymatic Evaluations of New Pyrazino[1,2-A]Indole-1,4-Dione-Indole-2-Phenylacetamides As Potent Inhibitors Against Α-Glucosidase and Α-Amylase JO - Chemistry and Biodiversity VL - 21 IS - 2 SP - EP - PY - 2024 ER -

Style

Citing Format

MLA

Ahmadi Shourkaei F, et al.. "Ugi Four-Multicomponent Reaction Based Synthesis, in Vitro, and in Silico Enzymatic Evaluations of New Pyrazino[1,2-A]Indole-1,4-Dione-Indole-2-Phenylacetamides As Potent Inhibitors Against Α-Glucosidase and Α-Amylase." Chemistry and Biodiversity, vol. 21, no. 2, 2024, pp. -.

APA

Ahmadi Shourkaei F, Rashidi Ranjbar P, Taslimi P, Mahdavi M (2024). Ugi Four-Multicomponent Reaction Based Synthesis, in Vitro, and in Silico Enzymatic Evaluations of New Pyrazino[1,2-A]Indole-1,4-Dione-Indole-2-Phenylacetamides As Potent Inhibitors Against Α-Glucosidase and Α-Amylase. Chemistry and Biodiversity, 21(2), -.

Chicago

Ahmadi Shourkaei F, Rashidi Ranjbar P, Taslimi P, Mahdavi M. "Ugi Four-Multicomponent Reaction Based Synthesis, in Vitro, and in Silico Enzymatic Evaluations of New Pyrazino[1,2-A]Indole-1,4-Dione-Indole-2-Phenylacetamides As Potent Inhibitors Against Α-Glucosidase and Α-Amylase." Chemistry and Biodiversity 21, no. 2 (2024): -.

Harvard

Ahmadi Shourkaei F et al. (2024) 'Ugi Four-Multicomponent Reaction Based Synthesis, in Vitro, and in Silico Enzymatic Evaluations of New Pyrazino[1,2-A]Indole-1,4-Dione-Indole-2-Phenylacetamides As Potent Inhibitors Against Α-Glucosidase and Α-Amylase', Chemistry and Biodiversity, 21(2), pp. -.

Vancouver

Ahmadi Shourkaei F, Rashidi Ranjbar P, Taslimi P, Mahdavi M. Ugi Four-Multicomponent Reaction Based Synthesis, in Vitro, and in Silico Enzymatic Evaluations of New Pyrazino[1,2-A]Indole-1,4-Dione-Indole-2-Phenylacetamides As Potent Inhibitors Against Α-Glucosidase and Α-Amylase. Chemistry and Biodiversity. 2024;21(2):-.

BibTex

@article{ author = {Ahmadi Shourkaei F and Rashidi Ranjbar P and Taslimi P and Mahdavi M}, title = {Ugi Four-Multicomponent Reaction Based Synthesis, in Vitro, and in Silico Enzymatic Evaluations of New Pyrazino[1,2-A]Indole-1,4-Dione-Indole-2-Phenylacetamides As Potent Inhibitors Against Α-Glucosidase and Α-Amylase}, journal = {Chemistry and Biodiversity}, volume = {21}, number = {2}, pages = {-}, year = {2024} }

RIS

TY - JOUR
AU - Ahmadi Shourkaei F
AU - Rashidi Ranjbar P
AU - Taslimi P
AU - Mahdavi M
TI - Ugi Four-Multicomponent Reaction Based Synthesis, in Vitro, and in Silico Enzymatic Evaluations of New Pyrazino[1,2-A]Indole-1,4-Dione-Indole-2-Phenylacetamides As Potent Inhibitors Against Α-Glucosidase and Α-Amylase
JO - Chemistry and Biodiversity
VL - 21
IS - 2
SP -
EP -
PY - 2024
ER -

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