Apoa Ii Genotypes Frequency and Their Interaction With Saturated Fatty Acids Consumption on Lipid Profile of Patients With Type 2 Diabetes Publisher Pubmed



Noorshahi N¹ ; Sotoudeh G² ; Djalali M¹ ; Eshraghian MR³ ; Keramatipour M⁴ ; Basiri MG¹ ; Doostan F⁵ ; Koohdani F^{1, 6}
Source: Clinical Nutrition Published:2016

Abstract

Background & aim: Several studies have suggested that APOA II-265T/C polymorphism affect lipid profile. The aim of this study was to investigate the effect of -265T/C APOA II polymorphism and saturated fatty acids (SFA) intake interaction on lipid profile in diabetic population who are at risk for lipid disorders. Methods: In this cross sectional study, 697 type 2 diabetic patients participated. Food consumption data were collected using validated semi-quantitative FFQ during the last year. Realtime-PCR was used to determine APOA II-265T/C genotypes. The interaction between the genotypes and SFA intake with lipid profile was tested using analysis of covariance (ANCOVA). Results: According to APOA II-265T/C (rs5082) genotype distribution results, CC genotype with a frequency of 12.9% and TC with that of 47.7% showed the lowest and highest frequency in our population, respectively. CC genotype subjects had significantly lower total cholesterol, triglyceride, Cholesterol/HDL-c ratio and non-HDL cholesterol than T allele carriers (p = 0.009, p = 0.02, p = 0.02 and p = 0.002, respectively). The interaction between genotype and SFA intake contributed to significant higher levels of LDL-c and LDL/HDL in CCs (p = 0.05 and p = 0.01), suggesting vulnerability of these individuals to high intake of SFA in the diet. Conclusion: APOA II polymorphism may influence the saturated fatty acid intake required to prevent dyslipidemia in the type 2 diabetic population. © 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism.