Association Between Dietary Inflammatory Index and Lipid Profiles With Consideration of Apo B Ins/ Del Snp in Type 2 Diabetic Patients Publisher



Mohamadinarab M¹ ; Yekaninejad MS² ; Siassi F³ ; Koohdani F⁴ Show Affiliations
Source: Meta Gene Published:2020

Abstract

Background and aims: Diabetes and dyslipidemia are worldwide worrying comorbidities. The Apolipoprotein B insertion/deletion (Apo B Ins / Del) polymorphism and dietary factors be involved in the metabolism of lipids and are related to diabetes incidence. Here, we aimed to investigate the association between dietary inflammatory index (DII) and lipid profile considering Apo B Ins/Del in patients with type 2 diabetes mellitus (T2D). Methods and results: This cross-sectional study was performed on a total of 599 T2D patients. A 148-item food frequency questionnaire (FFQ) was applied to assess the dietary intake of participants and DII score was calculated. Apo B Ins/Del polymorphism was genotyped by polymerase chain reaction (PCR). Linear regression was performed to assess the interaction between Ins/Del polymorphism Apo B gene and DII with Lipid Profile. There was only significant interaction between ApoB Ins/Del polymorphism and LDL cholesterol (β = −4.14, SE = 1.75, P = 0.01). Multivariate analysis was applied and after adjusting for confounders (age, gender, BMI, and total energy intake) the interaction remains significant (β = −3.82, SE = 1.76, P = 0.03). No significant interaction was observed between ApoB Ins/Del polymorphism and DII and other lipid profiles. There is also a significant association between DII with LDL, TC, and TG (p = 0.049, p = 0.038, and p = 0.045, respectively), among male T2D after modifying for confounders. This relation was not seen among female participants considering Apo B Ins/Del polymorphism. Conclusion: Higher adherence to the inflammatory diet may increase the levels of LDL-C and this association may be modified by Apo B polymorphism. © 2020 Elsevier B.V.