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Correlation Between Carotid Artery Mean Intima-Media Thickness and Brain Natriuretic Peptide in Patients With Psoriasis Publisher



Niknezhad N1 ; Shahididadras M1 ; Rajabi F1, 2 ; Khah HH3 ; Niknejad N4 ; Younespour S5
Authors
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Authors Affiliations
  1. 1. Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Network of Dermatology Research (NDR), Universal Scientific Education and Research Network (USERN, Tehran, Iran
  3. 3. Department of Radiology and Medical Imaging Center, Shohada-e Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. National Institute of Health Research, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Psoriasis and Psoriatic Arthritis Published:2022


Abstract

Background: Numerous studies have documented an association between psoriasis and subclinical atherosclerosis. Objective: We aimed to investigate the effects of psoriasis on the levels of N-terminal prohormone B type natriuretic peptide (NT-proBNP) and clarify whether this factor correlates with the evaluations of subclinical atherosclerosis, measured with mean intima-media thickness (MIMT) of the carotid artery. Methods: Sixty-one psoriatic patients and sixty-one healthy, age and sex-matched volunteers were enrolled. MIMT was assessed via ultrasonography and serum NT-proBNP level were measured by electrochemiluminescence. Results: Both NT-proBNP and MIMT were significantly higher in psoriasis patients. This remained true even after controlling for the effects of age and gender. MIMT was positively correlated with age and serum NT-proBNP level in both groups. Conclusions: In conclusion, NT-proBNP levels may be used as a predictor of subclinical atherosclerosis in patients with psoriasis. © The Author(s) 2022.
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1. Serum Osteopontin Level and Common Carotid Artery Intima-Media Wall Thickness in Psoriasis, International Journal of Dermatology (2016)
2. Echocardiographic and Electrocardiographic Assessments in Patients With Psoriasis, Caspian Journal of Internal Medicine (2021)
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