Hsp90 and Co-Chaperones: Impact on Tumor Progression and Prospects for Molecular-Targeted Cancer Therapy

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):

Share By

Hsp90 and Co-Chaperones: Impact on Tumor Progression and Prospects for Molecular-Targeted Cancer Therapy Publisher Pubmed

Jafari A^{1, 2} ; Rezaeitavirani M² ; Farhadihosseinabadi B³ ; Taranejoo S⁴ ; Zali H⁵

Source: Cancer Investigation Published:2020

Abstract

Heat shock protein 90 (HSP90), a highly and unique chaperone, presents as a double-edged sword. It plays an essential role in many physiological and pathological processes, including tumor development. The current review highlights a recent understanding of the roles of HSP90 in molecular mechanisms underlying cancer survival and progression. HSP90 and its client proteins through the regulation of oncoproteins including signaling proteins, receptors, and transcriptional factors involved in tumorigenesis. It also has potential clinical application as diagnostic and prognostic biomarkers for assessing cancer progression. In this way, using HSP90 to develop new anticancer therapeutic agents including HSP90 inhibitors, anti-HSP90 antibody, and HSP90-based vaccines has been promising. © 2020, © 2020 Taylor & Francis Group, LLC.

Related Docs

View other Related Docs

1. Bioinformatics Analysis of Hsp90 in Amniotic Fluid and Amniotic Membrane Cells As a Potential Anticancer Drug Target, Journal of Global Pharma Technology (2016)

2. Prediction of Dual Agents As an Activator of Mutant P53 and Inhibitor of Hsp90 by Docking, Molecular Dynamic Simulation and Virtual Screening, Journal of Molecular Graphics and Modelling (2015)

3. Discovering Therapeutic Protein Targets for Bladder Cancer Using Proteomic Data Analysis, Current Molecular Pharmacology (2020)

Experts (# of related papers)

Massoud Amanlou (5)

Mohammad Hossein Modarressi (1)

Other Related Docs

4. Prediction of New Hsp90 Inhibitors Based on 3,4-Isoxazolediamide Scaffold Using Qsar Study, Molecular Docking and Molecular Dynamic Simulation, DARU# Journal of Pharmaceutical Sciences (2017)

5. Damage-Associated Molecular Patterns in Tumor Radiotherapy, International Immunopharmacology (2020)

6. Autophagy Modulation in Breast Cancer Utilizing Nanomaterials and Nanoparticles, Frontiers in Oncology (2023)

7. 3D-Qsar, Molecular Docking, and Molecular Dynamic Simulations for Prediction of New Hsp90 Inhibitors Based on Isoxazole Scaffold, Journal of Biomolecular Structure and Dynamics (2018)

8. The Molecular Signature of Breast Cancer Metastasis to Bone, Anti-Cancer Drugs (2016)

9. The Role of the Tumor Microenvironment in Colorectal Cancer and the Potential Therapeutic Approaches, Journal of Clinical Laboratory Analysis (2022)

10. New Heat Shock Protein (Hsp90) Inhibitors, Designed by Pharmacophore Modeling and Virtual Screening: Synthesis, Biological Evaluation and Molecular Dynamics Studies, Journal of Biomolecular Structure and Dynamics (2020)

11. Immuno-Stimulating Peptide Derived From Hmgb1 Is More Effective Than the N-Terminal Domain of Gp96 As an Endogenous Adjuvant for Improvement of Protein Vaccines, Protein and Peptide Letters (2017)

12. Identification of New Hsp90 Inhibitors: Structure Based Virtual Screening, Molecular Dynamic Simulation, Synthesis and Biological Evaluation, Anti-Cancer Agents in Medicinal Chemistry (2021)

13. Engineered Tumor-Derived Extracellular Vesicles: Potentials in Cancer Immunotherapy, Frontiers in Immunology (2020)

14. Cancer Care Management During the Covid-19 Pandemic, Risk Management and Healthcare Policy (2020)

Style	Citing Format
MLA	Jafari A, et al.. "Hsp90 and Co-Chaperones: Impact on Tumor Progression and Prospects for Molecular-Targeted Cancer Therapy." Cancer Investigation, vol. 38, no. 5, 2020, pp. 310-328.
APA	Jafari A, Rezaeitavirani M, Farhadihosseinabadi B, Taranejoo S, Zali H (2020). Hsp90 and Co-Chaperones: Impact on Tumor Progression and Prospects for Molecular-Targeted Cancer Therapy. Cancer Investigation, 38(5), 310-328.
Chicago	Jafari A, Rezaeitavirani M, Farhadihosseinabadi B, Taranejoo S, Zali H. "Hsp90 and Co-Chaperones: Impact on Tumor Progression and Prospects for Molecular-Targeted Cancer Therapy." Cancer Investigation 38, no. 5 (2020): 310-328.
Harvard	Jafari A et al. (2020) 'Hsp90 and Co-Chaperones: Impact on Tumor Progression and Prospects for Molecular-Targeted Cancer Therapy', Cancer Investigation, 38(5), pp. 310-328.
Vancouver	Jafari A, Rezaeitavirani M, Farhadihosseinabadi B, Taranejoo S, Zali H. Hsp90 and Co-Chaperones: Impact on Tumor Progression and Prospects for Molecular-Targeted Cancer Therapy. Cancer Investigation. 2020;38(5):310-328.
BibTex	@article{ author = {Jafari A and Rezaeitavirani M and Farhadihosseinabadi B and Taranejoo S and Zali H}, title = {Hsp90 and Co-Chaperones: Impact on Tumor Progression and Prospects for Molecular-Targeted Cancer Therapy}, journal = {Cancer Investigation}, volume = {38}, number = {5}, pages = {310-328}, year = {2020} }
RIS	TY - JOUR AU - Jafari A AU - Rezaeitavirani M AU - Farhadihosseinabadi B AU - Taranejoo S AU - Zali H TI - Hsp90 and Co-Chaperones: Impact on Tumor Progression and Prospects for Molecular-Targeted Cancer Therapy JO - Cancer Investigation VL - 38 IS - 5 SP - 310 EP - 328 PY - 2020 ER -

Science Communicator Platform

Authors

Abstract