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The Molecular Signature of Breast Cancer Metastasis to Bone Publisher Pubmed



Bahrami T1 ; Mokmeli S2 ; Hossieni H3 ; Pourpaknia R4 ; Makani Z2 ; Salmaninejad A5 ; Estiar MA6 ; Hossieni A6 ; Farshbaf A4
Authors
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Authors Affiliations
  1. 1. Genetic Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, 1985713834, Iran
  2. 2. Department of Genetics, Faculty of Basic Sciences, Islamic Azad University, Zanjan Branch, Iran
  3. 3. Department of Molecular Biology, School of Basic Sciences, Persian Gulf University, Boushehr, Iran
  4. 4. Department of Medical Genetics, School of Medicine, Zanjan University, Zanjan, Iran
  5. 5. Medical Genetics Research Center, Mashhad University, Mashad, Iran
  6. 6. Department of Medical Genetics, School of Medicine, Tehran University, Tehran, Iran

Source: Anti-Cancer Drugs Published:2016


Abstract

Distant metastasis during the advanced stage of malignant tumor progression can cause considerable morbidity in cancer patients. Bone is known to be one of the most common sites of distant metastasis in patients with breast cancer (BC). BC metastases in bone are associated with excessive skeletal complications. These complications can be fatal and reduce quality of life of patients. It is important to understand the metastatic process of BC to bone to improve quality of life and design new therapeutic methods. At present, the molecular mechanisms leading to the BC metastasis to bone are not fully understood. Studying the molecular basis of BC metastasis to bone might improve our insight into this complex process. In addition, it can provide novel approaches for designing advanced and effective targeted therapies. The present article aimed to review the published papers on the molecular basis of the metastatic process of BC to bone, focusing on involved genes and signaling networks. Furthermore, we propose potential therapeutic targets that may be more effective for the inhibition and treatment of BC metastasis to bone. © 2016 Wolters Kluwer Health, Inc.
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