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Neuroinflammation As a Potential Therapeutic Target in Neuroimmunological Diseases Publisher



Amanollahi M1 ; Jameie M2, 3 ; Rezaei N1, 4, 5
Authors
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Authors Affiliations
  1. 1. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  2. 2. Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Neuroscience Research Center, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Translational Neuroimmunology: Neuroinflammation: Volume 7 Published:2023


Abstract

Neuroinflammatory processes are associated with inducing neurodegeneration and impairing neurogenesis. These processes are known to contribute to the underlying pathophysiology of various neurological disorders such as Parkinson’s disease (PD), Alzheimer’s disease (AD), stroke, multiple sclerosis (MS), and cognitive dysfunction. Therefore, targeting neuroinflammation may unlock new strategies to improve these conditions. This chapter discusses the recent findings regarding the therapeutic agents affecting neuroinflammation. We aimed to discuss the effects of herbal medicine and organic compounds, endogenous neuroactive substances, repurposed drugs (existing medications such as antibiotics, antidiabetic, etc. for new therapeutic purposes), and nonpharmacological approaches such as alcohol consumption and dietary modification on neuroinflammation. © 2023 Elsevier Inc. All rights reserved.
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