Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Early Onset Inflammatory Bowel Disease: Manifestations, Genetics and Diagnosis Publisher Pubmed



Moazzami B1, 2 ; Moazzami K3, 4 ; Rezaei N1, 5, 6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Student Research Committee, Babol University of Medical Sciences, Babol, Iran
  3. 3. Massachusetts General Hospital, Harvard Medical School, United States
  4. 4. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Boston, MA, United States
  5. 5. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Sheffield, United Kingdom

Source: Turkish Journal of Pediatrics Published:2019


Abstract

Moazzami B, Moazzami K, Rezaei N. Early onset inflammatory bowel disease: manifestations, genetics and diagnosis. Turk J Pediatr 2019; 61: 637-647. Crohn’s disease and ulcerative colitis are immunologically mediated chronic inflammatory conditions, collectively referred to as inflammatory bowel diseases (IBD). While most studies have described the condition in the adult population, recent evidences suggest that IBD in children may represent an etiologically distinct disease from the adult onset IBD. Since a significant proportion of patients diagnosed with IBD demonstrate their clinical manifestations during childhood, knowledge about the disease progression, severity and diagnosis in this particular patient population is crucial. Therefore, in the present study, the clinical manifestations, recent advancements in the genetics of early onset IBD and the clinical approach to diagnoses of IBD in children are described. © 2019, Turkish Journal of Pediatrics. All rights reserved.
Related Docs
View other Related Docs
1. Targeted Gene Panel Sequencing for Early-Onset Inflammatory Bowel Disease and Chronic Diarrhea, Inflammatory Bowel Diseases (2017)
2. A Practical Index to Distinguish Backwash Ileitis From Crohn's Terminal Ileitis in Mr Enterography, Inflammatory Bowel Diseases (2023)
3. Very Early Onset Inflammatory Bowel Disease: Investigation of the Il-10 Signaling Pathway in Iranian Children, European Journal of Medical Genetics (2017)
4. Common Variable Immunodeficiency: Epidemiology, Pathogenesis, Clinical Manifestations, Diagnosis, Classification, and Management, Journal of Investigational Allergology and Clinical Immunology (2020)
5. Comparison of the Extent of Pediatric Inflammatory Bowel Disease Based on Endo-Colonoscopy and Histological Findings, Immunopathologia Persa (2024)
6. Spectrum of Phenotypes Associated With Mutations in Lrba, Journal of Clinical Immunology (2016)
7. Apaf-1: Regulation and Function in Cell Death, Biochimie (2017)
8. Among Autophagy Genes, Atg16l1 But Not Irgm Is Associated With Crohn's Disease in Iranians, Gene (2018)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (12)
Pejman Rohani (4)
Other Related Docs
9. Clinical and Mutation Description of the First Iranian Cohort of Infantile Inflammatory Bowel Disease: The Iranian Primary Immunodeficiency Registry (Ipidr), Immunological Investigations (2020)
10. Evaluation of Expression of Lrba and Ctla-4 Proteins in Common Variable Immunodeficiency Patients, Immunological Investigations (2022)
11. Leishmaniasis and Autoimmunity in Patient With Lps-Responsive Beige-Like Anchor Protein (Lrba) Deficiency, Endocrine# Metabolic and Immune Disorders - Drug Targets (2020)
12. The Role of Bacteria in the Inflammatory Bowel Disease Development: A Narrative Review, APMIS (2018)
13. Prevalence of Hepatobiliary Manifestations in Inflammatory Bowel Disease: A Grade Assessed Systematic Review and Meta-Analysis of More Than 1.7 Million Patients, Journal of Crohn's and Colitis (2024)
14. The Heterogeneous Pathogenesis of Selective Immunoglobulin a Deficiency, International Archives of Allergy and Immunology (2019)
15. Frequency and Geographic Distribution of Card9 Mutations in Patients With Severe Fungal Infections, Frontiers in Microbiology (2018)
16. Identifying Novel Mutations in Iranian Patients With Lps-Responsive Beige-Like Anchor Protein (Lrba) Deficiency, Immunological Investigations (2021)
17. Clinical, Immunologic, and Molecular Spectrum of Patients With Lps-Responsive Beige-Like Anchor Protein Deficiency: A Systematic Review, Journal of Allergy and Clinical Immunology: In Practice (2019)
18. The Extended Phenotype of Lps-Responsive Beige-Like Anchor Protein (Lrba) Deficiency, Journal of Allergy and Clinical Immunology (2016)
19. Methylation in Colorectal Cancer, Epigenetics Territory and Cancer (2015)
20. Autoimmune Disorders Associated With Common Variable Immunodeficiency: Prediction, Diagnosis, and Treatment, Expert Review of Clinical Immunology (2022)
21. Impaired Il-23–Dependent Induction of Ifn-Γ Underlies Mycobacterial Disease in Patients With Inherited Tyk2 Deficiency, Journal of Experimental Medicine (2022)
22. Monogenic Polyautoimmunity in Primary Immunodeficiency Diseases, Autoimmunity Reviews (2018)
23. Association of Food Allergies, Cow’S Milk Allergy, and Asthma With Pediatric Inflammatory Bowel Disease, Acta Medica Iranica (2018)
24. Candidiasis Associated With Very Early Onset Inflammatory Bowel Disease: First Il10rb Deficient Case From the National Iranian Registry and Review of the Literature, Clinical Immunology (2019)
25. Defects in Innate Immunity: Receptors and Signaling Components, Encyclopedia of Infection and Immunity (2022)
26. Comparison of Disease Phenotype and Course Among Elderly- and Early-Onset Inflammatory Bowel Diseases in the Middle East, Archives of Iranian Medicine (2023)
27. Polyautoimmunity in Patients With Lps-Responsive Beige-Like Anchor (Lrba) Deficiency, Immunological Investigations (2018)
28. Severe Disseminated Phaeohyphomycosis in a Patient With Inherited Card9 Deficiency, Archives of Clinical Infectious Diseases (2018)
29. Immunopathogenesis of Ankylosing Spondylitis: An Updated Review, Acta Medica Iranica (2018)
30. Long-Term Outcome of Lrba Deficiency in 76 Patients After Various Treatment Modalities As Evaluated by the Immune Deficiency and Dysregulation Activity (Idda) Score, Journal of Allergy and Clinical Immunology (2020)
31. Antibiotics With Therapeutic Effects on Spinal Cord Injury: A Review, Fundamental and Clinical Pharmacology (2021)
32. A Mechanistic Review on Plant-Derived Natural Compounds As Dietary Supplements for Prevention of Inflammatory Bowel Disease, Expert Review of Gastroenterology and Hepatology (2016)
33. Dietary Anthocyanins As a Complementary Medicinal Approach for Management of Inflammatory Bowel Disease, Expert Review of Gastroenterology and Hepatology (2015)
34. Whole-Exome Sequencing to Identify Undiagnosed Primary Immunodeficiency Disorders in Children With Community-Acquired Sepsis, Admitted in the Pediatric Intensive Care Unit, Pediatric Allergy and Immunology (2023)
35. Diagnostic Challenges in the Early Onset of Inflammatory Bowel Disease: A Case Report, International Journal of Molecular and Cellular Medicine (2018)
36. Mycobacterium Avium Subsp. Paratuberculosis and Associated Risk Factors for Inflammatory Bowel Disease in Iranian Patients, Gut Pathogens (2017)
37. Dietary Patterns and Risk of Inflammatory Bowel Disease: A Systematic Review of Observational Studies, Inflammatory Bowel Diseases (2024)
38. Primary Immunodeficiency Diseases in Iran: Past, Present and Future, Archives of Iranian Medicine (2021)