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Clinical Features, Risk Factors, and Management of Candida Keratitis Publisher Pubmed



Masoumi A1 ; Soleimani M1 ; Azizkhani M1 ; Izadi A1 ; Cheraqpour K1 ; Tabatabaei SA1 ; Khodaveisi S1 ; Aminzadeh M1
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Source: Ocular Immunology and Inflammation Published:2023


Abstract

Background/Aims: To determine the clinical features, predisposing factors, and management of infectious keratitis caused by Candida spp. Methods: Retrospective chart review. Results: The medical records of 52 patients (54 eyes) with Candida keratitis were available for statistical analysis. Thinning of the corneal stroma was identified in 34 eyes (63.0%), and corneal perforation occurred in 16 eyes (29.6%). Corneal thinning and perforation were more common in Candida albicans compared with non-albicans (P-val <.001, P =.09, respectively). The most common predisposing factors for Candida keratitis were topical steroid use (21 patients, 40.4%), previous corneal transplantation (17 patients, 32.7%), and preexisting ocular surface disease (15 patients, 28.8%). Fourteen eyes (25.9%) required cyanoacrylate glue application and 10 eyes (18.5%) underwent therapeutic penetrating keratoplasty (TPK). Conclusion: Local immunosuppression and ocular surface disease play an important role in Candida keratitis. C. albicans appears to be more invasive compared with non-albicans spp. © 2023 Taylor & Francis Group, LLC.
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