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Tandem Synthesis of Benzo[D]Naphtho[2,3-G][1,3]Oxazocine-8,13(6H,14H)-Dione Derivatives Publisher



Madani Qamsari F1 ; Moradi S1 ; Foroumadi A2 ; Mahdavi M3 ; Moghimi A4
Authors
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Authors Affiliations
  1. 1. Department of Chemistry, Tehran North Branch, Islamic Azad University, Tehran, Iran
  2. 2. Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Chemistry, Imam Hossein University, Tehran, Iran

Source: Monatshefte fur Chemie Published:2019


Abstract

Abstract: An efficient and facile method for the synthesis of novel naphthooxazocines from 2-hydroxy-1,4-naphthoquinone and quinolinium salts at room temperature is described. The reaction proceeds through C-alkylation and intramolecular O-alkylation, affording the desired products in good yields. © 2019, Springer-Verlag GmbH Austria, part of Springer Nature.