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Recent Randomized Trials of Antithrombotic Therapy for Patients With Covid-19: Jacc State-Of-The-Art Review Publisher Pubmed



Talasaz AH1, 2 ; Sadeghipour P3 ; Kakavand H1, 2 ; Aghakouchakzadeh M1 ; Kordzadehkermani E1 ; Van Tassell BW4, 5 ; Gheymati A1 ; Ariannejad H2 ; Hosseini SH1 ; Jamalkhani S3 ; Sholzberg M6, 7 ; Monreal M8 ; Jimenez D9 ; Piazza G10 Show All Authors
Authors
  1. Talasaz AH1, 2
  2. Sadeghipour P3
  3. Kakavand H1, 2
  4. Aghakouchakzadeh M1
  5. Kordzadehkermani E1
  6. Van Tassell BW4, 5
  7. Gheymati A1
  8. Ariannejad H2
  9. Hosseini SH1
  10. Jamalkhani S3
  11. Sholzberg M6, 7
  12. Monreal M8
  13. Jimenez D9
  14. Piazza G10
  15. Parikh SA11, 12
  16. Kirtane AJ11, 12
  17. Eikelboom JW13
  18. Connors JM14
  19. Hunt BJ15
  20. Konstantinides SV16, 17
  21. Cushman M18, 19
  22. Weitz JI20, 21
  23. Stone GW11, 22
  24. Krumholz HM23, 24, 25
  25. Lip GYH26, 27
  26. Goldhaber SZ10
  27. Bikdeli B10, 11, 23
Show Affiliations
Authors Affiliations
  1. 1. Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Pharmacotherapy and Outcome Science, School of Pharmacy, Virginia Commonwealth University, Richmond, VA, United States
  5. 5. Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, School of Pharmacy, Virginia Commonwealth University, Richmond, VA, United States
  6. 6. Departments of Medicine and Laboratory Medicine & Pathobiology, University of Toronto, Toronto, ON, Canada
  7. 7. Department of Medicine, St. Michael's Hospital, Toronto, ON, Canada
  8. 8. Department of Internal Medicine, Hospital Universitari Germans Trials i Pujol, Universidad Catolica San Antonio de Murcia, Barcelona, Spain
  9. 9. Respiratory Department, Hospital Ramon y Cajal and Medicine Department, Universidad de Alcala (Instituto de Ramon y Cajal de Investigacion Sanitaria), Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias, Madrid, Spain
  10. 10. Cardiovascular Medicine Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
  11. 11. Clinical Trials Center, Cardiovascular Research Foundation, New York, NY, United States
  12. 12. NewYork-Presbyterian Hospital/Columbia University Irving Medical Center, New York, NY, United States
  13. 13. Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, ON, Canada
  14. 14. Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
  15. 15. Haemostasis and Thrombosis Centre, St. Thomas' Hospital, London, United Kingdom
  16. 16. Center for Thrombosis and Hemostasis, Johannes Gutenberg University of Mainz, Mainz, Germany
  17. 17. Department of Cardiology, Democritus University of Thrace, Komotini, Greece
  18. 18. Department of Medicine, University of Vermont Larner College of Medicine and University of Vermont Medical Center, Burlington, VT, United States
  19. 19. Department of Pathology and Laboratory Medicine, University of Vermont Larner College of Medicine and University of Vermont Medical Center, Burlington, VT, United States
  20. 20. Department of Medicine, McMaster University, Hamilton, ON, Canada
  21. 21. Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada
  22. 22. Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States
  23. 23. Center for Outcomes Research and Evaluation (CORE), Yale School of Medicine, New Haven, CT, United States
  24. 24. Department of Health Policy and Administration, Yale School of Public Health, New Haven, CT, United States
  25. 25. Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, United States
  26. 26. Liverpool Centre for Cardiovascular Science, Liverpool Heart and Chest Hospital, University of Liverpool, Liverpool, United Kingdom
  27. 27. Department of Clinical Medicine, Aalborg University, Aalborg, Denmark

Source: Journal of the American College of Cardiology Published:2021


Abstract

Endothelial injury and microvascular/macrovascular thrombosis are common pathophysiological features of coronavirus disease-2019 (COVID-19). However, the optimal thromboprophylactic regimens remain unknown across the spectrum of illness severity of COVID-19. A variety of antithrombotic agents, doses, and durations of therapy are being assessed in ongoing randomized controlled trials (RCTs) that focus on outpatients, hospitalized patients in medical wards, and patients critically ill with COVID-19. This paper provides a perspective of the ongoing or completed RCTs related to antithrombotic strategies used in COVID-19, the opportunities and challenges for the clinical trial enterprise, and areas of existing knowledge, as well as data gaps that may motivate the design of future RCTs. © 2021 American College of Cardiology Foundation
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