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Pten and Mir-26B: Promising Prognostic Biomarkers in Initiation and Progression of Oral Squamous Cell Carcinoma Publisher Pubmed



Baghaei F1 ; Abdollahi A2 ; Mohammadpour H3 ; Jahanbin M4 ; Naseri Taheri F4 ; Aminishakib P1 ; Emami Razavi A3 ; Kharazifard M5
Authors
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Authors Affiliations
  1. 1. Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Cancer Biology Research Center, Iran National Tumor Bank, Cancer Institute Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Oral Pathology and Medicine Published:2019


Abstract

Backgrounds: Oral Squamous Cell Carcinoma (OSCC) is the most common malignancy of the oral cavity. Phosphatase and TENsin homolog (PTEN) is a well-known tumor suppressive gene regulated by several biomarkers including a small single-stranded molecule, microRNA26b (miR-26b). Here, we studied the expression of PTEN and miR-26b in OSCC specimens in comparison with adjacent normal mucosa. Methods: The expressions of PTEN and miR-26b genes were evaluated at mRNA level in OSCC and adjacent normal fresh frozen tissues in 49 patients using Quantitative Real-Time PCR and analyzed their associations with clinicopathological factors. Results: The expression level of PTEN was significantly lower in OSCC specimens comparing with adjacent normal tissues (P-value = 0.000). The expression of PTEN was associated with T stage (P-value = 0.006) and N stage (P-value = 0.043). A nonsignificant decrease in miR-26b expression level was also observed in OSCC tissues. Additionally, in patients with more aggressive tumoral behavior, including vascular invasion (P-value = 0.012) and positive N stage (P-value = 0.02), significant decreases were found. Conclusions: These findings suggest that inactivation of PTEN may have an impact on initiation and progression of OSCC. Additionally, miR-26b might have a tumor suppressive role in OSCC. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
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