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A Global Action Agenda for Turning the Tide on Fatty Liver Disease Publisher Pubmed



Lazarus JV1, 2, 3 ; Mark HE4, 5 ; Allen AM6 ; Arab JP7, 8, 9 ; Carrieri P10 ; Noureddin M11 ; Alazawi W12 ; Alkhouri N13 ; Alqahtani SA14 ; Anstee QM15 ; Arrese M9 ; Bataller R16 ; Berg T17 ; Brennan PN18 Show All Authors
Authors
  1. Lazarus JV1, 2, 3
  2. Mark HE4, 5
  3. Allen AM6
  4. Arab JP7, 8, 9
  5. Carrieri P10
  6. Noureddin M11
  7. Alazawi W12
  8. Alkhouri N13
  9. Alqahtani SA14
  10. Anstee QM15
  11. Arrese M9
  12. Bataller R16
  13. Berg T17
  14. Brennan PN18
  15. Burra P19
  16. Castronarro GE20, 21, 22
  17. Cortezpinto H23
  18. Cusi K24
  19. Dedes N25
  20. Duseja A26
  21. Francque SM27, 28
  22. Gastaldelli A29
  23. Hagstrom H30
  24. Huang TTK3, 31
  25. Wajcman DI1
  26. Kautz A32
  27. Kopka CJ33
  28. Krag A34
  29. Newsome PN35
  30. Rinella ME36
  31. Romero D37
  32. Sarin SK38
  33. Silva M39
  34. Spearman CW40
  35. Terrault NA41
  36. Tsochatzis EA42
  37. Valenti L43, 44
  38. Villotarivas M1
  39. Zelbersagi S45, 46
  40. Schattenberg JM47
  41. Wong VWS48
  42. Younossi ZM49
  43. Aberg F50
  44. Adams LA51
  45. Alnaamani K52
  46. Albadawy RM53
  47. Alexa Z54
  48. Allison M55
  49. Alnaser FA56
  50. Alswat K57
  51. Alvaresdasilva MR58
  52. Alvaro D59
  53. Alvesbezerra M60
  54. Andrade RJ61
  55. Awuku YA62
  56. Baatarkhuu O63
  57. Baffy G64
  58. Bakieva SR65
  59. Bansal MB66
  60. Barouki R67
  61. Batterham RL68
  62. Behling C69
  63. Belfortdeaguiar R70
  64. Berzigotti A71
  65. Betel M72
  66. Bianco C73
  67. Bosi E74
  68. Boursier J75
  69. Brunt EM76
  70. Bugianesi E77
  71. Byrne CJ78
  72. Cabrejos MCC79
  73. Caldwell S80
  74. Carr R81
  75. Fernandez MIC82
  76. Castera L83
  77. Castillolopez MG84
  78. Caussy C85
  79. Cerdareyes E86
  80. Ceriello A87
  81. Chan WK88
  82. Chang Y89
  83. Charatcharoenwitthaya P90
  84. Chaveztapia N91
  85. Chung RT92
  86. Colombo M93
  87. Coppell KJ94
  88. Cotrim HP95
  89. Craxi A96
  90. Crespo J97
  91. Dassanayake A98
  92. Davidson NO99
  93. De Knegt RJ100
  94. De Ledinghen V101
  95. Demir M102
  96. Desalegn H103
  97. Diago M104
  98. Dillon JF78
  99. Dimmig B105
  100. Dirac MA106
  101. Dirchwolf M107
  102. Dufour JF108
  103. Dvorak K109
  104. Ekstedt M110
  105. Elkassas M111
  106. Elsanousi OM112
  107. Elsharkawy AM35
  108. Elwakil RM113
  109. Eskridge W114
  110. Eslam M115
  111. Esmat G116
  112. Fan JG117
  113. Ferraz ML118
  114. Flisiak R119
  115. Fortin D10
  116. Fouad Y120
  117. Friedman SL66
  118. Fuchs M121
  119. Gadano A122
  120. Geerts A123
  121. Geier A124
  122. George J115
  123. Gerber LH125
  124. Ghazinyan HL126
  125. Gheorghe L127
  126. Kile DG128
  127. Girala M29, 129
  128. Bee GGB130
  129. Goossens N131
  130. Graupera I132
  131. Gronbaek H133
  132. Hamid S134
  133. Hebditch V135
  134. Henry Z80
  135. Hickman IJ136
  136. Hobbs LA3
  137. Hocking SL137
  138. Hofmann WP138
  139. Idilman R139
  140. Iruzubieta P97
  141. Isaacs S140
  142. Isakov VA141
  143. Ismail MH142
  144. Jamal MH143
  145. Jarvis H144
  146. Jepsen P133
  147. Jornayvaz FR145
  148. Sudhamshu KC146
  149. Kakizaki S147
  150. Karpen S148
  151. Kawaguchi T149
  152. Keating SE150
  153. Khader Y151
  154. Kim SU152
  155. Kim W153
  156. Kleiner DE154
  157. Koek G155
  158. Komas NPJ156
  159. Kondili LA157
  160. Koot BG158
  161. Korenjak M159
  162. Kotsiliti E160
  163. Koulla Y161
  164. Kugelmas C162
  165. Kugelmas M163
  166. Labidi A164
  167. Lange NF165
  168. Lazo M166
  169. Leite N167
  170. Lin HC168
  171. Lkhagvaa U63
  172. Long MT169
  173. Lopezjaramillo P170
  174. Lozano A171
  175. Macedo MP172
  176. Malekzadeh R173
  177. Marchesini G174
  178. Marciano S122
  179. Martinez K175
  180. Martinez Vazquez SE21
  181. Mateva L176
  182. Mato JM177
  183. Mbendi CN178
  184. Mccary AG179
  185. Mcintyre J180
  186. Mckee M181
  187. Mendive JM182
  188. Mikolasevic I183
  189. Miller PS184
  190. Milovanovic T185
  191. Milton T186
  192. Morenoalcantar R187
  193. Morgan TR188
  194. Motala AA189
  195. Muris J190
  196. Musso C191
  197. Navagonzalez EJ192
  198. Negro F193
  199. Nersesov AV194
  200. Neuschwandertetri BA195
  201. Nikolova D196
  202. Norris S197
  203. Novak K198
  204. Ocama P199
  205. Ong JP200
  206. Onggo A201
  207. Onyekwere C202
  208. Padillamachaca PM203
  209. Pais R204
  210. Pan CQ205
  211. Panduro A206
  212. Panigrahi MK207
  213. Papatheodoridis G208
  214. Paruk I189
  215. Patel K209
  216. Penhagoncalves C210
  217. Perez NM211
  218. Perezescobar J212
  219. Pericas JM213
  220. Perseghin G214
  221. Pessoa MG215
  222. Petta S216
  223. De Oliveira CPMS217
  224. Prabhakaran D218
  225. Pryke R219
  226. Pyrsopoulos N220
  227. Rabiee A221
  228. Ramji A222
  229. Ratziu V223
  230. Ravendhran N224
  231. Ray K225
  232. Roden M226
  233. Romeo S227
  234. Romerogomez M228
  235. Rotman Y229
  236. Rouabhia S230
  237. Rowe IA231
  238. Sadirova S232
  239. Alkhatry MS233
  240. Salupere R234
  241. Satapathy SK235
  242. Schwimmer JB236
  243. Sebastiani G237
  244. Seim L238
  245. Seki Y239
  246. Serme AK240
  247. Shapiro D241
  248. Sharvadze L242
  249. Shaw JE243
  250. Shawa IT244
  251. Shenoy T245
  252. Shibolet O246
  253. Shimakawa Y247
  254. Shubrook JH248
  255. Singh SP249
  256. Sinkala E250
  257. Skladany L251
  258. Skrypnyk I252
  259. Song MJ253
  260. Sookoian S254
  261. Soriano JB255
  262. Sridharan K256
  263. Stefan N257
  264. Stine JG258
  265. Stratakis N1
  266. Sheriff DS259
  267. Sundaram SS260
  268. Svegliatibaroni G261
  269. Swain MG262
  270. Tacke F102
  271. Taheri S263
  272. Tan SS264
  273. Tapper EB265
  274. Targher G266
  275. Tcaciuc E267
  276. Thiele M34
  277. Tiniakos D268
  278. Tolmane I269
  279. Torre A270
  280. Torres EA271
  281. Treeprasertsuk S272
  282. Trenell M273
  283. Turcan S267
  284. Turcanu A267
  285. Valantinas J274
  286. Van Kleef LA100
  287. Velasco JAVR275
  288. Vesterhus M276
  289. Vilargomez E277
  290. Waked I278
  291. Wattacheril J279
  292. Wedemeyer H280
  293. Wilkins F281
  294. Willemse J282
  295. Wong RJ283
  296. Yilmaz Y284
  297. Ykijarvinen H285
  298. Yu ML286
  299. Yumuk V287
  300. Zeybel M288
  301. Zheng KI289
  302. Zheng MH289

Source: Hepatology Published:2023


Abstract

Background and Aims: Fatty liver disease is a major public health threat due to its very high prevalence and related morbidity and mortality. Focused and dedicated interventions are urgently needed to target disease prevention, treatment, and care. Approach and Results: We developed an aligned, prioritized action agenda for the global fatty liver disease community of practice. Following a Delphi methodology over 2 rounds, a large panel (R1 n = 344, R2 n = 288) reviewed the action priorities using Qualtrics XM, indicating agreement using a 4-point Likert-scale and providing written feedback. Priorities were revised between rounds, and in R2, panelists also ranked the priorities within 6 domains: epidemiology, treatment and care, models of care, education and awareness, patient and community perspectives, and leadership and public health policy. The consensus fatty liver disease action agenda encompasses 29 priorities. In R2, the mean percentage of “agree” responses was 82.4%, with all individual priorities having at least a super-majority of agreement (> 66.7% “agree”). The highest-ranked action priorities included collaboration between liver specialists and primary care doctors on early diagnosis, action to address the needs of people living with multiple morbidities, and the incorporation of fatty liver disease into relevant non-communicable disease strategies and guidance. Conclusions: This consensus-driven multidisciplinary fatty liver disease action agenda developed by care providers, clinical researchers, and public health and policy experts provides a path to reduce fatty liver disease prevalence and improve health outcomes. To implement this agenda, concerted efforts will be needed at the global, regional, and national levels. Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.
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