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Nomenclature and Definition of Metabolic-Associated Fatty Liver Disease: A Consensus From the Middle East and North Africa Publisher Pubmed



Shiha G1, 2 ; Alswat K3 ; Al Khatry M4 ; Sharara AI5 ; Ormeci N6 ; Waked I7 ; Benazzouz M8 ; Alali F9 ; Hamed AE10 ; Hamoudi W11 ; Attia D12 ; Derbala M13 ; Sharafeldin M14 ; Albusafi SA15 Show All Authors
Authors
  1. Shiha G1, 2
  2. Alswat K3
  3. Al Khatry M4
  4. Sharara AI5
  5. Ormeci N6
  6. Waked I7
  7. Benazzouz M8
  8. Alali F9
  9. Hamed AE10
  10. Hamoudi W11
  11. Attia D12
  12. Derbala M13
  13. Sharafeldin M14
  14. Albusafi SA15
  15. Zaky S16
  16. Bamakhrama K17
  17. Ibrahim N18
  18. Ajlouni Y19
  19. Sabbah M20
  20. Salama M7
  21. Anushiravani A21
  22. Afredj N22
  23. Barakat S23
  24. Hashim A24
  25. Fouad Y25
  26. Soliman R1, 26

Source: The Lancet Gastroenterology and Hepatology Published:2021


Abstract

With the increasing prevalence of obesity and type 2 diabetes, fatty liver disease associated with metabolic dysfunction is a global health problem, especially because it is one of the earliest consequences of obesity and it precedes diabetes development. Fatty liver disease associated with metabolic dysfunction is of particular concern in the Middle East and north Africa, where its prevalence is greater than that in the rest of the world. Despite the magnitude of the problem, no regional guidelines have been developed to address this disease. This Review describes suggestions of redefining fatty liver disease associated with metabolic dysfunction, including its terminology and criteria for diagnosis. Experts have raised serious concerns on the current nomenclature, which labels the disease as non-alcoholic fatty liver disease (NAFLD), and its diagnostic criteria. The panel reached a consensus that the disease should be renamed as metabolic-associated fatty liver disease (MAFLD) and that the disease should be diagnosed by positive criteria. The aim is now to work with authorities across the region to implement these proposed changes and reflect them in health-care policy and to improve health care for patients in this region. © 2021 Elsevier Ltd
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