Collagen Sponge Functionalized With Chimeric Anti-Bmp-2 Monoclonal Antibody Mediates Repair of Critical-Size Mandibular Continuity Defects in a Nonhuman Primate Model

Collagen Sponge Functionalized With Chimeric Anti-Bmp-2 Monoclonal Antibody Mediates Repair of Critical-Size Mandibular Continuity Defects in a Nonhuman Primate Model Publisher Pubmed

Xie Y^{1, 2} ; Su Y¹ ; Min S³ ; Tang J⁴ ; Goh BT⁵ ; Saigo L⁵ ; Ansari S⁶ ; Moshaverinia A⁷ ; Zhang C¹ ; Wang J^{1, 8} ; Liu Y² ; Khojasteh A⁹ ; Zadeh HH³ ; Wang S^{1, 8}

Show Affiliations

1. Molecular Laboratory for Gene Therapy and Tooth Regeneration, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Tian Tan Xi Li No. 4, Beijing, 100050, China
2. Laboratory of Tissue Regeneration and Immunology, Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Tian Tan Xi Li No. 4, Beijing, 100050, China
3. Laboratory for Immunoregulation and Tissue Engineering (LITE), Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, United States
4. Department of Oral and Maxillofacial Surgery, Xiangya Stomatological Hospital, Central South University, Changsha, Hunan, China
5. Department of Oral and Maxillofacial Surgery, National Dental Centre, Singapore
6. Division of Growth and Development, School of Dentistry, University of California, Los Angeles, CA, United States
7. Division of Advanced Prosthodontics, School of Dentistry, University of California, Los Angeles, CA, United States
8. Department of Biochemistry and Molecular Biology, Capital Medical University School of Basic Medical Sciences, You An Men Wai Xi Tou Tiao No. 10, Beijing, 100069, China
9. Department of Tissue Engineering, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: BioMed Research International Published:2017

Abstract

Antibody-mediated osseous regeneration (AMOR) has been introduced by our research group as a tissue engineering approach to capture of endogenous growth factors through the application of specific monoclonal antibodies (mAbs) immobilized on a scaffold. Specifically, anti-Bone Morphogenetic Protein- (BMP-) 2 mAbs have been demonstrated to be efficacious in mediating bone repair in a number of bone defects. The present study sought to investigate the application of AMOR for repair of mandibular continuity defect in nonhuman primates. Critical-sized mandibular continuity defects were created in Macaca fascicularis locally implanted with absorbable collagen sponges (ACS) functionalized with chimeric anti-BMP-2 mAb or isotype control mAb. 2D and 3D analysis of cone beam computed tomography (CBCT) imaging demonstrated increased bone density and volume observed within mandibular continuity defects implanted with collagen scaffolds functionalized with anti-BMP-2 mAb, compared with isotype-matched control mAb. Both CBCT imaging and histologic examination demonstrated de novo bone formation that was in direct apposition to the margins of the resected bone. It is hypothesized that bone injury may be necessary for AMOR. This is evidenced by de novo bone formation adjacent to resected bone margins, which may be the source of endogenous BMPs captured by anti-BMP-2 mAb, in turn mediating bone repair. Copyright © 2017 Yilin Xie et al.

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Style	Citing Format
MLA	Xie Y, et al.. "Collagen Sponge Functionalized With Chimeric Anti-Bmp-2 Monoclonal Antibody Mediates Repair of Critical-Size Mandibular Continuity Defects in a Nonhuman Primate Model." BioMed Research International, vol. 2017, no. , 2017, pp. -.
APA	Xie Y, Su Y, Min S, Tang J, Goh BT, Saigo L, Ansari S, Moshaverinia A, Zhang C, Wang J, Liu Y, Khojasteh A, Zadeh HH, Wang S (2017). Collagen Sponge Functionalized With Chimeric Anti-Bmp-2 Monoclonal Antibody Mediates Repair of Critical-Size Mandibular Continuity Defects in a Nonhuman Primate Model. BioMed Research International, 2017(), -.
Chicago	Xie Y, Su Y, Min S, Tang J, Goh BT, Saigo L, Ansari S, et al.. "Collagen Sponge Functionalized With Chimeric Anti-Bmp-2 Monoclonal Antibody Mediates Repair of Critical-Size Mandibular Continuity Defects in a Nonhuman Primate Model." BioMed Research International 2017, no. (2017): -.
Harvard	Xie Y et al. (2017) 'Collagen Sponge Functionalized With Chimeric Anti-Bmp-2 Monoclonal Antibody Mediates Repair of Critical-Size Mandibular Continuity Defects in a Nonhuman Primate Model', BioMed Research International, 2017(), pp. -.
Vancouver	Xie Y, Su Y, Min S, Tang J, Goh BT, Saigo L, et al.. Collagen Sponge Functionalized With Chimeric Anti-Bmp-2 Monoclonal Antibody Mediates Repair of Critical-Size Mandibular Continuity Defects in a Nonhuman Primate Model. BioMed Research International. 2017;2017():-.
BibTex	@article{ author = {Xie Y and Su Y and Min S and Tang J and Goh BT and Saigo L and Ansari S and Moshaverinia A and Zhang C and Wang J and Liu Y and Khojasteh A and Zadeh HH and Wang S}, title = {Collagen Sponge Functionalized With Chimeric Anti-Bmp-2 Monoclonal Antibody Mediates Repair of Critical-Size Mandibular Continuity Defects in a Nonhuman Primate Model}, journal = {BioMed Research International}, volume = {2017}, number = {}, pages = {-}, year = {2017} }
RIS	TY - JOUR AU - Xie Y AU - Su Y AU - Min S AU - Tang J AU - Goh BT AU - Saigo L AU - Ansari S AU - Moshaverinia A AU - Zhang C AU - Wang J AU - Liu Y AU - Khojasteh A AU - Zadeh HH AU - Wang S TI - Collagen Sponge Functionalized With Chimeric Anti-Bmp-2 Monoclonal Antibody Mediates Repair of Critical-Size Mandibular Continuity Defects in a Nonhuman Primate Model JO - BioMed Research International VL - 2017 IS - SP - EP - PY - 2017 ER -

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