Amino Acid-Assisted Green Synthesis of a Porous Binary Oxide Nanocomposite for Sensitive Electrochemical Detection of Chlorpromazine Publisher Pubmed



Zinatlooajabshir S ; Pardakhti A ; Mahmoudimoghaddam H ; Akbari Javar H
Source: Scientific Reports Published:2025

Abstract

In this work, an eco-friendly method was used to synthesize cerium–bismuth oxide nanostructures as a binary oxide nanocomposite. For this purpose, L-alanine was utilized as a novel and green fuel to produce a nanostructured Bi2O3–CeO2 sample. The prepared porous CeO2–Bi2O3 NPs and ionic liquid were used to develop a new sensor (Pr–CeO2–Bi2O3/IL/CPE) for detecting Chlorpromazine (CLP). The study showed that the present electrode has good electrochemical performance for CLP detection under a diffusion-controlled procedure. The chronoamperometric method was utilized to calculate the diffusion coefficient (D) of CLP, which was found to be 1.47 × 10–5 cm2 s− 1. The DPV technique was employed to establish the calibration curve, demonstrating a linear range of 0.02–140 µM and achieving a detection limit (LOD) of 9 nM. The prepared sensor also showed suitable repeatability and reproducibility. The practical applicability of Pr–CeO2–Bi2O3/IL/CPE for detecting CLP in various real samples showed good sensitivity and selectivity. © 2025 Elsevier B.V., All rights reserved.