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Radiofrequency Ablation of Parathyroid Adenomas Causing Primary Hyperparathyroidism: A Report of 27 Patients Publisher Pubmed



Ebrahiminik H1 ; Chegeni H2 ; Mosadegh Khah A3 ; Salouti R4 ; Ghomashchi G4 ; Deldar Pasikhani M5 ; Heydari I6 ; Shamsi K7 ; Beiranvand B8 ; Azimi Aval MR9 ; Mohammadi A10 ; Mirzaaghazadehattari M11 ; Fadaee N12
Authors
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Authors Affiliations
  1. 1. Department of Interventional Radiology and Radiation Sciences Research Center, Aja University of Medical Sciences, Tehran, Iran
  2. 2. Tirad Imaging Institute, Tehran, Iran
  3. 3. Department of Endocrinology, Aja University of Medical Sciences, Tehran, Iran
  4. 4. Interventional Radiology Department, Tirad Imaging Institute, Tehrn, Iran
  5. 5. Department of Obstetrics and Gynecology, School of Medicine, Vali Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Endocrinology Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Lorestan University of Medical Sciences, Khorramabad, Iran
  9. 9. Department of Radiology, Shiraz University of Medical Sciences, Shiraz, Iran
  10. 10. Department of Radiology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
  11. 11. Medical Radiation Sciences Research Group, Tabriz University of Medical Sciences, Tabriz, Iran
  12. 12. Department of Family Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Clinical Ultrasound Published:2022


Abstract

Purpose: To study treatment outcome of parathyroid adenomas using ultrasound-guided radiofrequency ablation. Methods: Twenty-seven patients with a single adenoma of the parathyroid gland were included in the study. Using color Doppler ultrasonography, the lesion and its characteristics were determined, and dextrose was injected to dissect the gland from the surrounding structures. The ablation process was done with 6–12 watts of power. Results: No complications were seen in any of the subjects. A significant reduction was seen in serum parathyroid hormone (PTH) and calcium levels after treatment. PTH levels showed a median decrease of 13.8%, and a median decrease of 8.2% was seen in serum calcium levels (p < 0.001). Phosphorus levels did not change significantly after treatment. In 1-month follow-up of patients, the lesion size had decreased considerably. In long-term follow-up, 11 of 20 patients having subsequent imaging had indistinguishable lesions. Conclusion: Our results showed that RFA of parathyroid adenomas caused a significant reduction in biomedical indicators of disease and resulted in a significant reduction or disappearance of the lesion in the majority of the patients while having no considerable complications. © 2022 Wiley Periodicals LLC.