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Genetic and Epigenetic Alterations in Parathyroid Neoplasms Publisher



Yazdi SAM1 ; Nazar E2
Authors
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Authors Affiliations
  1. 1. Department of General Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pathology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Pathology Published:2022


Abstract

The exact etiology of parathyroid carcinomas (PC) is still unknown. Their associations have with several inherited syndromes or specific genetic lesions have been established. The management of PC is challenging for clinicians. The complexity of molecular phenotypes increases with tumor aggressiveness. Lack of parafibromin on immunohistochemistry staining and HRPT2 mutation would be helpful in differentiation of carcinoma from adenoma. Lack of parafibromin expression, the gene product of HRPT2 is now used as a diagnostic, prognostic, and predictive marker for parathyroid carcinoma. The epigenetic alteration, for example, DNA methylation and modifications in the chromatin structure, are known as significant events involved in the parathyroid tumorigenesis. We suggest that adjuvant genetic and epigenetic target therapy should be considered in treatment of the patients with PC. © 2022, Iranian Society of Pathology. All rights reserved.
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