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Bicyclic Peptides: Types, Synthesis and Applications Publisher Pubmed



Ahangarzadeh S1 ; Kanafi MM4 ; Hosseinzadeh S4 ; Mokhtarzadeh A5 ; Barati M6 ; Ranjbari J2, 3 ; Tayebi L7
Authors

Source: Drug Discovery Today Published:2019


Abstract

Bicyclic peptides form one of the most promising platforms for drug development owing to their biocompatibility, similarity and chemical diversity to proteins, and they are considered as a possible practical tool in various therapeutic and diagnostic applications. Bicyclic peptides are known to have the capability of being employed as an effective alternative to complex molecules, such as antibodies, or small molecules. This review provides a summary of the recent progress on the types, synthesis and applications of bicyclic peptides. More specifically, natural and synthetic bicyclic peptides are introduced with their different production methods and relevant applications, including drug targeting, imaging and diagnosis. Their uses as antimicrobial agents, as well as the therapeutic functions of different bicyclic peptides, are also discussed. © 2019 Elsevier Ltd
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