Bicyclic Peptides: Types, Synthesis and Applications

Bicyclic Peptides: Types, Synthesis and Applications Publisher Pubmed

Ahangarzadeh S¹ ; Kanafi MM⁴ ; Hosseinzadeh S⁴ ; Mokhtarzadeh A⁵ ; Barati M⁶ ; Ranjbari J^{2, 3} ; Tayebi L⁷

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1. Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2. Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
6. Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran
7. Marquette University School of Dentistry, Milwaukee, 53233, WI, United States

Source: Drug Discovery Today Published:2019

Abstract

Bicyclic peptides form one of the most promising platforms for drug development owing to their biocompatibility, similarity and chemical diversity to proteins, and they are considered as a possible practical tool in various therapeutic and diagnostic applications. Bicyclic peptides are known to have the capability of being employed as an effective alternative to complex molecules, such as antibodies, or small molecules. This review provides a summary of the recent progress on the types, synthesis and applications of bicyclic peptides. More specifically, natural and synthetic bicyclic peptides are introduced with their different production methods and relevant applications, including drug targeting, imaging and diagnosis. Their uses as antimicrobial agents, as well as the therapeutic functions of different bicyclic peptides, are also discussed. © 2019 Elsevier Ltd

Style	Citing Format
MLA	Ahangarzadeh S, et al.. "Bicyclic Peptides: Types, Synthesis and Applications." Drug Discovery Today, vol. 24, no. 6, 2019, pp. 1311-1319.
APA	Ahangarzadeh S, Kanafi MM, Hosseinzadeh S, Mokhtarzadeh A, Barati M, Ranjbari J, Tayebi L (2019). Bicyclic Peptides: Types, Synthesis and Applications. Drug Discovery Today, 24(6), 1311-1319.
Chicago	Ahangarzadeh S, Kanafi MM, Hosseinzadeh S, Mokhtarzadeh A, Barati M, Ranjbari J, Tayebi L. "Bicyclic Peptides: Types, Synthesis and Applications." Drug Discovery Today 24, no. 6 (2019): 1311-1319.
Harvard	Ahangarzadeh S et al. (2019) 'Bicyclic Peptides: Types, Synthesis and Applications', Drug Discovery Today, 24(6), pp. 1311-1319.
Vancouver	Ahangarzadeh S, Kanafi MM, Hosseinzadeh S, Mokhtarzadeh A, Barati M, Ranjbari J, et al.. Bicyclic Peptides: Types, Synthesis and Applications. Drug Discovery Today. 2019;24(6):1311-1319.
BibTex	@article{ author = {Ahangarzadeh S and Kanafi MM and Hosseinzadeh S and Mokhtarzadeh A and Barati M and Ranjbari J and Tayebi L}, title = {Bicyclic Peptides: Types, Synthesis and Applications}, journal = {Drug Discovery Today}, volume = {24}, number = {6}, pages = {1311-1319}, year = {2019} }
RIS	TY - JOUR AU - Ahangarzadeh S AU - Kanafi MM AU - Hosseinzadeh S AU - Mokhtarzadeh A AU - Barati M AU - Ranjbari J AU - Tayebi L TI - Bicyclic Peptides: Types, Synthesis and Applications JO - Drug Discovery Today VL - 24 IS - 6 SP - 1311 EP - 1319 PY - 2019 ER -

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Abstract