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The Types and Applications of Peptibodies Publisher



Nemati M1 ; Ahmadi A2 ; Hashemzehi A3 ; Nasrullozoda F4 ; Abedi M5 ; Hashemzaei M1
Authors
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Authors Affiliations
  1. 1. Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Department of Biomedical Engineering, Sahand University of Technology, Tabriz, Iran
  3. 3. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Department of Advanced Technologies, North Khorasan University of Medical Sciences, Bojnurd, Iran

Source: International Journal of Peptide Research and Therapeutics Published:2024


Abstract

Peptides as drugs are a promising therapeutic method. Peptides modulate diverse biological processes and are synthesized with high purity. Due to their low cell permeability, peptide drugs target extracellular receptors. The peptibody comprises the biologically active Fc region and the peptide itself. Various peptides with specific biological activities have been successfully fused into the Fc region. These peptide-Fc fusions, also known as peptibodies, offer an excellent therapeutic alternative to monoclonal antibodies. They comprise biologically active peptides bound to the Fc region. This approach retains antibodies' beneficial characteristics, especially the enhanced affinity resulting from Fc dimerization and extended plasma residence time. Peptibodies can be produced in Escherichia coli using recombinant methods. In this study, we describe peptibodies and analyze different types of peptibodies collected for research. © 2023, The Author(s), under exclusive licence to Springer Nature B.V.
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