Comparison of Efficacy of Granisetron and Promethazine in Control of Hyperemesis Gravidarum Publisher



Aleyasin A¹ ; Saffarieh E⁵ ; Torkamandi H² ; Hanafi S² ; Sadeghi F² ; Mahdavi A¹ ; Bahmaei F¹ ; Javadi M^{3, 4}
Source: Journal of Obstetrics and Gynecology of India Published:2016

Abstract

Purpose: Hyperemesis gravidarum is the third leading cause of hospitalization during pregnancy. 5-HT3-receptor antagonists are the most effective against chemotherapy-induced nausea and vomiting and radiation. This randomized study aimed to compare and evaluate the efficacies of granisetron and promethazine for controlling nausea and vomiting of pregnancy. Methods: The included patients were administered (oral and intravenous) granisetron and promethazine randomly. The patients were evaluated for nausea and vomiting by a senior gynecology resident blinded to designated drugs. Results: This study revealed that granisetron significantly decreased nausea and vomiting in pregnant women (pi¿½