Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Mitochondrial Transplantation for Cardioprotection and Induction of Angiogenesis in Ischemic Heart Disease Publisher Pubmed



Hassanpour P1, 2 ; Sadeghsoltani F1 ; Saghebasl S1 ; Boroumand S3 ; Khanicheragh P4 ; Tafti SHA3 ; Rahbarghazi R1, 5 ; Rahmati M1, 2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Department of Clinical Biochemistry and Laboratory Medicine, Tabriz University of Medical Sciences, Tabriz, 5166614766, Iran
  3. 3. Research Center for Advanced Technologies In Cardiovascular Medicine, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Student Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, 5166653431, Iran

Source: Stem Cell Research and Therapy Published:2025


Abstract

To date, the regenerative potential of mitochondrial transplantation (MT) has been extensively investigated under several pathologies. Among various cardiovascular diseases, ischemic heart disease (IHD), the most prevalent pathological condition in human medicine, is induced by coronary artery narrowing, or occlusion, leading to bulk necrotic changes and fibrosis within the myocardium. Data associated with the pro-angiogenic activity of mitochondria have not been completely elucidated in terms of cardiac tissue regeneration. Here, we aimed to highlight the recent studies and advantages related to the application of mitochondrial mass in the ischemic myocardium. How and by which mechanisms, mitochondria can reduce aberrant myocardial tissue remodeling via different pathways such as angiogenesis and de novo blood formation was discussed in detail. We hope that data from the current review article help us understand the molecular and cellular mechanisms by which transplanted mitochondria exert their regenerative properties in the ischemic myocardium. © The Author(s) 2025.
Related Docs
View other Related Docs
1. Mitochondria-Loaded Alginate-Based Hydrogel Accelerated Angiogenesis in a Rat Model of Acute Myocardial Infarction, International Journal of Biological Macromolecules (2024)
2. Mitotherapy in Doxorubicin Induced Cardiotoxicity: A Promising Strategy to Reduce the Complications of Treatment, Life Sciences (2022)
3. Mechanisms Behind Therapeutic Potentials of Mesenchymal Stem Cell Mitochondria Transfer/Delivery, Journal of Controlled Release (2023)
4. Mitotherapy, an Attractive Avenue for the Future Medicine, Mitochondrial Metabolism: An Approach to Disease Management (2021)
5. The Burden of Cardiovascular Disease Attributable to Modifiable Risk Factors and Cost-Effectiveness Analysis of Irapen Program in the General Population of Iran, Medical Journal of the Islamic Republic of Iran (2022)
6. The Effect of Meal Replacements Therapy on Blood Pressure and C-Reactive Protein: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Clinical Hypertension (2025)
7. Impact of Polyphenols on Heart Failure and Cardiac Hypertrophy: Clinical Effects and Molecular Mechanisms, Frontiers in Cardiovascular Medicine (2023)
8. Burden of Ischemic Heart Disease and Its Attributable Risk Factors in North Africa and the Middle East, 1990 to 2019: Results From the Gbd Study 2019, Journal of the American Heart Association (2024)
Experts (# of related papers)
View all Related Experts
Bagher Larijani (3)
Farshad Farzadfar (2)
Other Related Docs
9. The Association Between Glycemic Index, Glycemic Load and Total Carbohydrate Intake and Risk of Premature Coronary Artery Disease: Iran Premature Coronary Artery Disease Study (Ipad) - a Case-Control Study, Nutrition# Metabolism and Cardiovascular Diseases (2024)
10. Effects of Camelina Oil Supplementation on Lipid Profile and Glycemic Control: A Systematic Review and Dose‒Response Meta-Analysis of Randomized Clinical Trials, Lipids in Health and Disease (2022)
11. Reactive Oxygen Species-Mediated Cardiac-Reperfusion Injury: Mechanisms and Therapies, Life Sciences (2016)
12. A 30-Year Trend of Ischemic Heart Disease Burden in a Developing Country; a Systematic Analysis of the Global Burden of Disease Study 2019 in Iran, International Journal of Cardiology (2023)
13. Personalized Evaluation of the Passive Myocardium in Ischemic Cardiomyopathy Via Computational Modeling Using Bayesian Optimization, Biomechanics and Modeling in Mechanobiology (2024)
14. The Footprint of Kynurenine Pathway in Cardiovascular Diseases, International Journal of Tryptophan Research (2022)
15. Target Sestrin2 to Rescue the Damaged Organ: Mechanistic Insight Into Its Function, Oxidative Medicine and Cellular Longevity (2021)
16. The Beneficial Effects of Mesenchymal Stem Cells and Their Exosomes on Myocardial Infarction and Critical Considerations for Enhancing Their Efficacy, Ageing Research Reviews (2023)
17. Legume Consumption and Risk of All-Cause and Cause-Specific Mortality: A Systematic Review and Dose–Response Meta-Analysis of Prospective Studies, Advances in Nutrition (2023)
18. Dietary Intake, Biomarkers and Supplementation of Fatty Acids and Risk of Coronary Events: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials and Prospective Observational Studies, Critical Reviews in Food Science and Nutrition (2023)