Association Between Interleukin 2 Receptor a Gene Polymorphisms (Rs2104286 and Rs12722489) With Susceptibility to Multiple Sclerosis in Iranian Population

Association Between Interleukin 2 Receptor a Gene Polymorphisms (Rs2104286 and Rs12722489) With Susceptibility to Multiple Sclerosis in Iranian Population Publisher

Pourakbari R^{1, 2} ; Hosseini M³ ; Aslani S⁴ ; Ayoubijoshaghani MH⁵ ; Valizadeh H⁶ ; Roshangar L⁷ ; Ahmadi M⁷ ; Shirvani B⁸

Show Affiliations

1. Student's Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
2. Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran
3. Department of Science, Islamshahr Branch, Islamic Azad University, Islamshahr, Tehran, Iran
4. Rheumatology Research Center, Tehran University of Medical Sciences, PO Box: 1411713137, Tehran, Iran
5. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
6. Tuberculosis and Lung Disease Research Center of Tabriz University of Medical Sciences, Tabriz, Iran
7. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
8. Faculty of Nursing and Midwifery, Islamic Azad University Isfahan (Khorasgan) Branch, Isfahan, Iran

Source: Meta Gene Published:2020

Abstract

Multiple sclerosis (MS) is an organ-specific autoimmune disorder with remarkable heritability. For MS disorder, interleukin 2 receptor α subunit (IL2RA) is regarded as a genetic risk factor. There was a statistically significant association between alleles and genotypes of rs12722489 SNP and MS risk. The levels of mRNA expression and serum IL-2RA were higher in MS patients than in healthy controls. mRNA expression and serum concentrations of IL-2RA were higher in MS patients with CC genotype for rs12722489 compared with the rest of patients. Our result demonstrate that the rs12722489 SNP within IL2RA gene might be associated with MS pathogenesis through regulating the levels of IL-2RA (or CD25), which is important in the regulation of T cells. © 2020 Elsevier B.V.

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Style	Citing Format
MLA	Pourakbari R, et al.. "Association Between Interleukin 2 Receptor a Gene Polymorphisms (Rs2104286 and Rs12722489) With Susceptibility to Multiple Sclerosis in Iranian Population." Meta Gene, vol. 25, no. , 2020, pp. -.
APA	Pourakbari R, Hosseini M, Aslani S, Ayoubijoshaghani MH, Valizadeh H, Roshangar L, Ahmadi M, Shirvani B (2020). Association Between Interleukin 2 Receptor a Gene Polymorphisms (Rs2104286 and Rs12722489) With Susceptibility to Multiple Sclerosis in Iranian Population. Meta Gene, 25(), -.
Chicago	Pourakbari R, Hosseini M, Aslani S, Ayoubijoshaghani MH, Valizadeh H, Roshangar L, Ahmadi M, Shirvani B. "Association Between Interleukin 2 Receptor a Gene Polymorphisms (Rs2104286 and Rs12722489) With Susceptibility to Multiple Sclerosis in Iranian Population." Meta Gene 25, no. (2020): -.
Harvard	Pourakbari R et al. (2020) 'Association Between Interleukin 2 Receptor a Gene Polymorphisms (Rs2104286 and Rs12722489) With Susceptibility to Multiple Sclerosis in Iranian Population', Meta Gene, 25(), pp. -.
Vancouver	Pourakbari R, Hosseini M, Aslani S, Ayoubijoshaghani MH, Valizadeh H, Roshangar L, et al.. Association Between Interleukin 2 Receptor a Gene Polymorphisms (Rs2104286 and Rs12722489) With Susceptibility to Multiple Sclerosis in Iranian Population. Meta Gene. 2020;25():-.
BibTex	@article{ author = {Pourakbari R and Hosseini M and Aslani S and Ayoubijoshaghani MH and Valizadeh H and Roshangar L and Ahmadi M and Shirvani B}, title = {Association Between Interleukin 2 Receptor a Gene Polymorphisms (Rs2104286 and Rs12722489) With Susceptibility to Multiple Sclerosis in Iranian Population}, journal = {Meta Gene}, volume = {25}, number = {}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Pourakbari R AU - Hosseini M AU - Aslani S AU - Ayoubijoshaghani MH AU - Valizadeh H AU - Roshangar L AU - Ahmadi M AU - Shirvani B TI - Association Between Interleukin 2 Receptor a Gene Polymorphisms (Rs2104286 and Rs12722489) With Susceptibility to Multiple Sclerosis in Iranian Population JO - Meta Gene VL - 25 IS - SP - EP - PY - 2020 ER -

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