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Evaluation of the Effect of Bmscs Condition Media and Methylprednisolone in Tgf-Β Expression and Functional Recovery After an Acute Spinal Cord Injury Publisher Pubmed



Khoshsirat S1 ; Abbaszadeh HA1, 2, 6 ; Ahrabi B2 ; Bahrami M2 ; Abdollahi Far MA2 ; Khoramgah MS3 ; Roozbahany NA1, 4 ; Darabi S5
Authors
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Authors Affiliations
  1. 1. Hearing Disorders Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Biology and Anatomical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. G. Raymond Chang School, Ryerson University, Toronto, Canada
  5. 5. Cellular and Molecular Research Center, Qazvin University of Medical Science, Qazvin, Iran
  6. 6. Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Bratislava Medical Journal Published:2018


Abstract

The purpose of this experimental study is evaluation of the effect of BMSCs Condition Media and Methylprednisolone in TGF-β expression and functional recovery after acute spinal cord injury in adult wistar rat. MATERIAL AND METHODS: After an acute spinal cord injury, MP and BMSC-CM were injected intraperitoneally and the recovery rate was evaluated by BBB and narrow beam test. Real time PCR, H & E staining, cavity formation and stereology was done after 12 weeks post injury. RESULT: There were signifi cant differences in functional recovery between MP+CM group, relative to other groups. TGF-β1 expression decreased in MP+CM group compared to the control group. Cavity size in experimental groups decreased compared to the control group. The mean volume of spinal cord demonstrated a signifi cant increase in the MP+CM group in comparison to the other experimental groups. CONCLUSION: Simultaneous use of MP and BMSC-CM will improve recovery from the spinal cord injury, reduce infl ammation and improve functional recovery (Tab. 1, Fig. 8, Ref. 26). Text in PDF www.elis.sk. © AEPress s.r.o.
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