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Evaluation of the Effect of Bmscs Condition Media and Methylprednisolone in Tgf-Β Expression and Functional Recovery After an Acute Spinal Cord Injury Publisher Pubmed



Khoshsirat S1 ; Abbaszadeh HA1, 2, 6 ; Ahrabi B2 ; Bahrami M2 ; Abdollahi Far MA2 ; Khoramgah MS3 ; Roozbahany NA1, 4 ; Darabi S5
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Source: Bratislava Medical Journal Published:2018


Abstract

The purpose of this experimental study is evaluation of the effect of BMSCs Condition Media and Methylprednisolone in TGF-β expression and functional recovery after acute spinal cord injury in adult wistar rat. MATERIAL AND METHODS: After an acute spinal cord injury, MP and BMSC-CM were injected intraperitoneally and the recovery rate was evaluated by BBB and narrow beam test. Real time PCR, H & E staining, cavity formation and stereology was done after 12 weeks post injury. RESULT: There were signifi cant differences in functional recovery between MP+CM group, relative to other groups. TGF-β1 expression decreased in MP+CM group compared to the control group. Cavity size in experimental groups decreased compared to the control group. The mean volume of spinal cord demonstrated a signifi cant increase in the MP+CM group in comparison to the other experimental groups. CONCLUSION: Simultaneous use of MP and BMSC-CM will improve recovery from the spinal cord injury, reduce infl ammation and improve functional recovery (Tab. 1, Fig. 8, Ref. 26). Text in PDF www.elis.sk. © AEPress s.r.o.
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