Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Micrornas As Novel Diagnostic Biomarkers in Endometriosis Patients: A Systematic Review and Meta-Analysis Publisher Pubmed



Zafari N1 ; Bahramy A2 ; Majidi Zolbin M3 ; Emadi Allahyari S1 ; Farazi E4 ; Hassannejad Z5 ; Yekaninejad MS6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  3. 3. Pediatric Urology and Regenerative Medicine Research Center, Section of Tissue Engineering and Stem Cells Therapy, Children’s Hospital Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medicine, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
  5. 5. Pediatric Urology and Regenerative Medicine Research Center, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Expert Review of Molecular Diagnostics Published:2022


Abstract

Objective: To investigate whether miRNAs have a remarkable pooled diagnostic accuracy, sensitivity, and specificity as noninvasive biomarkers to distinguish endometriosis patients from non-endometriosis women. Methods: A comprehensive literature search of PubMed, Embase, and ProQuest was performed through February 21, 2021 to find relevant studies. Two reviewers independently screened each article, and discrepancies were resolved by consensus. Deeks’ funnel plot asymmetry test was performed to assess the publication bias of included studies. The STATA software and RevMan 5.4 were used for data analysis and quality assessment, respectively. Results: The overall quality of the studies was moderate to high. In total 87 datasets were assessed miRNAs’ performance which results in sensitivity: 0.82, specificity: 0.79, DOR: 18, NPV: 0.80, PPV: 0.78, PLR: 3.97, and NLR: 022. We conducted subgroup analyses, which showed panels of miRNAs (DOR: 54) and serum (DOR: 43) as a target tissue was more reliable to utilize as biomarkers. Deeks’ funnel plot showed that there is no publication bias (P-value = 0.25). Conclusions: Panels of miRNAs differentiate endometriosis patients from non-endometriosis women with high sensitivity and specificity; therefore, it has the potential to use as a noninvasive biomarker. © 2021 Informa UK Limited, trading as Taylor & Francis Group.
Related Docs
View other Related Docs
1. Identification of Candidate Microrna Markers of Endometriosis With the Use of Next-Generation Sequencing and Quantitative Real-Time Polymerase Chain Reaction, Fertility and Sterility (2020)
2. A Panel of Plasma Mirnas 199B-3P, 224-5P and Let-7D-3P As Non-Invasive Diagnostic Biomarkers for Endometriosis, Reproductive Sciences (2021)
3. The Role of Mirnas 340-5P, 92A-3P, and 381-3P in Patients With Endometriosis: A Plasma and Mesenchymal Stem-Like Cell Study, BioMed Research International (2021)
4. Micrornas and Exosomes: Cardiac Stem Cells in Heart Diseases, Pathology Research and Practice (2022)
5. Exosomes and Micrornas in Biomedical Science, Synthesis Lectures on Biomedical Engineering (2022)
6. Role of Resveratrol in Modulating Micrornas in Human Diseases: From Cancer to Inflammatory Disorder, Current Medicinal Chemistry (2021)
7. Investigating the Expressions of Mirna-125B and Tp53 in Endometriosis. Does It Underlie Cancer-Like Features of Endometriosis? a Case-Control Study, International Journal of Reproductive BioMedicine (2020)
8. The Potential for Circulating Micrornas in the Diagnosis of Myocardial Infarction: A Novel Approach to Disease Diagnosis and Treatment, Current Pharmaceutical Design (2016)
Experts (# of related papers)
View all Related Experts
Hamid Reza Mirzaei (5)
Pantea Izadi (2)
Other Related Docs
9. The Landscape of Non-Coding Rnas in the Immunopathogenesis of Endometriosis, Frontiers in Immunology (2023)
10. New Epigenetic Players in Stroke Pathogenesis: From Non-Coding Rnas to Exosomal Non-Coding Rnas, Biomedicine and Pharmacotherapy (2021)
11. Apoptotic Functions of Micrornas in Pathogenesis, Diagnosis, and Treatment of Endometriosis, Cell and Bioscience (2020)
12. Circulating Micrornas As Diagnostic and Therapeutic Biomarkers in Gastric and Esophageal Cancers, Journal of Cellular Physiology (2018)
13. Gynecologic Cancers and Non-Coding Rnas: Epigenetic Regulators With Emerging Roles, Critical Reviews in Oncology/Hematology (2021)
14. Microrna Signature of Regulatory T Cells in Health and Autoimmunity, Biomedicine and Pharmacotherapy (2018)
15. Mir-495–3P As a Promising Tumor Suppressor in Human Cancers, Pathology Research and Practice (2023)
16. Pharmacological Effects of Β-D-Mannuronic Acid (M2000) on Mir-146A, Irak1, Traf6 and Nf-Κb Gene Expression, As Target Molecules in Inflammatory Reactions, Pharmacological Reports (2017)
17. The Role of Micrornas in Different Types of Thyroid Carcinoma: A Comprehensive Analysis to Find New Mirna Supplementary Therapies, Journal of Endocrinological Investigation (2018)
18. Microrna Biogenesis and Function, Synthesis Lectures on Biomedical Engineering (2022)
19. A Review of Molecular Interplay Between Neurotrophins and Mirnas in Neuropsychological Disorders, Molecular Neurobiology (2022)
20. Targeting Mirnas With Anesthetics in Cancer: Current Understanding and Future Perspectives, Biomedicine and Pharmacotherapy (2021)
21. A Bioinformatics Approach to the Identification of Variants Associated With Type 1 and Type 2 Diabetes Mellitus That Reside in Functionally Validated Mirnas Binding Sites, Biochemical Genetics (2016)
22. The Effect of Prednisolone on Mir 15A and Mir16-1 Expression Levels and Apoptosis in Acute Lymphoblastic Leukemia Cell Line: Ccrf-Cem, Drug Research (2016)
23. Extracellular Vesicles in Acute Leukemia: A Mesmerizing Journey With a Focus on Transferred Micrornas, Frontiers in Cell and Developmental Biology (2021)
24. The Effect of Increased Mir-16-1 Levels in Mouse Embryos on Epigenetic Modification, Target Gene Expression, and Developmental Processes, Reproductive Sciences (2020)
25. The Role of Oncomirs in the Pathogenesis and Treatment of Breast Cancer, Biomedicine and Pharmacotherapy (2016)
26. Microrna Profiling During Germline Differentiation of Mouse Embryonic Stem Cells, Cellular and Molecular Biology (2015)
27. Epigenetic Alterations Underlying Autoimmune Diseases, Autoimmunity (2016)
28. Differential Role of Micrornas in Prognosis, Diagnosis, and Therapy of Ovarian Cancer, Biomedicine and Pharmacotherapy (2016)
29. Micrornas in Female Infertility: An Overview, Cell Biochemistry and Function (2021)
30. A Crosstalk Between Epigenetic Modulations and Non-Alcoholic Fatty Liver Disease Progression, Pathology Research and Practice (2023)
31. Micrornas and Long Non-Coding Rnas As Biomarkers for Polycystic Ovary Syndrome, Journal of Cellular and Molecular Medicine (2022)
32. Focus on the Role of Nlrp3 Inflammasome in the Pathology of Endometriosis: A Review on Molecular Mechanisms and Possible Medical Applications, Naunyn-Schmiedeberg's Archives of Pharmacology (2023)
33. Micrornas-Based Imaging Techniques in Cancer Diagnosis and Therapy, Journal of Cellular Biochemistry (2017)
34. Pancreatic Islet Differentiation of Human Embryonic Stem Cells by Microrna Overexpression, Journal of Tissue Engineering and Regenerative Medicine (2016)
35. Mirnas in Outer Membrane Vesicles of Gut Microbiota: Friend or Foe?, Microbial Pathogenesis (2020)
36. The Pre-Mir-27A Variant Rs895819 May Contribute to Type 2 Diabetes Mellitus Susceptibility in an Iranian Cohort, Journal of Endocrinological Investigation (2016)
37. Investigation of Tgf-Β1 Gene Variant and Expression in a Group of Iranian Women With Endometriosis, Archives of Gynecology and Obstetrics (2021)
38. Differential Expression of Let-7 Microrna in Patients With Coronary Artery Disease: Possible Potential for Early Diagnosis, Treatment, and Prevention, International Cardiovascular Research Journal (2023)
39. The Salivary Exosomal Microrna As a Potential Biomarker in Patients With Periodontitis and Oral Cancers, Chemical Biology and Drug Design (2023)
40. Microrna Expression in Infertile Men: Its Alterations and Effects, Zygote (2019)
41. The Pathogenic, Therapeutic and Diagnostic Role of Exosomal Microrna in the Autoimmune Diseases, Journal of Neuroimmunology (2021)
42. Recent Advances on High-Efficiency of Micrornas in Different Types of Lung Cancer: A Comprehensive Review, Cancer Cell International (2023)
43. Exosomal Micrornas in Regulation of Tumor Cells Resistance to Apoptosis, Biochemistry and Biophysics Reports (2024)
44. Prognostic and Diagnostic Values of Non-Coding Rnas As Biomarkers for Breast Cancer: An Umbrella Review and Pan-Cancer Analysis, Frontiers in Molecular Biosciences (2023)
45. Implications of the Noncoding Rnas in Rheumatoid Arthritis Pathogenesis, Journal of Cellular Physiology (2018)
46. Genetic Aspects of Idiopathic Asthenozoospermia As a Cause of Male Infertility, Human Fertility (2020)
47. Mirnas Derived From Cancer-Associated Fibroblasts in Colorectal Cancer, Epigenomics (2019)
48. The Association Analysis of Vascular Endothelial Growth Factor-2549 Insertion/ Deletion Variant and Endometriosis Risk, International Journal of Molecular and Cellular Medicine (2019)
49. Anti-Inflammatory Micrornas and Their Potential for Inflammatory Diseases Treatment, Frontiers in Immunology (2018)
50. Testicular Mirnas in Relation to Spermatogenesis, Spermatogonial Stem Cells and Cancer/Testis Genes, Scientific African (2019)