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Mesenchymal Stem Cells and Natural Killer Cells Interaction Mechanisms and Potential Clinical Applications Publisher Pubmed



Abbasi B1, 2 ; Shamsasenjan K1, 3 ; Ahmadi M4 ; Beheshti SA1, 2 ; Saleh M5
Authors
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Authors Affiliations
  1. 1. Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Stem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Department of Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Stem Cell Research and Therapy Published:2022


Abstract

Natural killer cells (NK cells) are innate immune cells that are activated to fight tumor cells and virus-infected cells. NK cells also play an important role in the graft versus leukemia response. However, they can over-develop inflammatory reactions by secreting inflammatory cytokines and increasing Th1 differentiation, eventually leading to tissue damage. Today, researchers have attributed some autoimmune diseases and GVHD to NK cells. On the other hand, it has been shown that mesenchymal stem cells (MSCs) can modulate the activity of NK cells, while some researchers have shown that NK cells can cause MSCs to lysis. Therefore, we considered it is necessary to investigate the effect of these two cells and their signaling pathway in contact with each other, also their clinical applications. © 2022, The Author(s).
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