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Smart Mesoporous Silica Nanoparticles for Controlled-Release Drug Delivery Publisher



Karimi M1 ; Mirshekari H2 ; Aliakbari M3 ; Sahandizangabad P4 ; Hamblin MR5, 6, 7
Authors
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Authors Affiliations
  1. 1. Faculty of Advanced Technologies in Medicine, Department of Medical Nanotechnology, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Advanced Nanobiotechnology and Nanomedicine Research Group (ANNRG), Iran University of Medical Sciences, Tehran, Iran
  3. 3. Medical Laboratory Sciences, Kerman University of Medical Science, Kerman, Iran
  4. 4. Department of Materials Science and Engineering, Sharif University of Technology, P.O. Box 11365-9466, Tehran, 14588, Iran
  5. 5. Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, 02114, MA, United States
  6. 6. Department of Dermatology, Harvard Medical School, Boston, 02115, MA, United States
  7. 7. Harvard-MIT Division of Health Sciences and Technology, Cambridge, 02139, MA, United States

Source: Nanotechnology Reviews Published:2016


Abstract

Stimuli-responsive controlled-release nanocarriers are promising vehicles for delivery of bioactive molecules that can minimize side effects and maximize efficiency. The release of the drug occurs when the nanocarrier is triggered by an internal or external stimulus. Mesoporous silica nanoparticles (MSN) can have drugs and bioactive cargos loaded into the high-capacity pores, and their release can be triggered by activation of a variety of stimulus-responsive molecular gatekeepers or nanovalves. In this mini-review, we discuss the basic concepts of MSN in targeted drug-release systems and cover different stimulus-responsive gatekeepers. Internal stimuli include redox, enzymes, and pH, while external stimuli include light, ultrasound, and magnetic fields, and temperature can either be internal or external. © 2016 by De Gruyter.
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