The Combination of Metformin With Morin Alleviates Hepatic Steatosis Via Modulating Hepatic Lipid Metabolism, Hepatic Inflammation, Brown Adipose Tissue Thermogenesis, and White Adipose Tissue Browning in High-Fat Diet-Fed Mice

The Combination of Metformin With Morin Alleviates Hepatic Steatosis Via Modulating Hepatic Lipid Metabolism, Hepatic Inflammation, Brown Adipose Tissue Thermogenesis, and White Adipose Tissue Browning in High-Fat Diet-Fed Mice Publisher Pubmed

Tehrani SS¹ ; Goodarzi G¹ ; Panahi G¹ ; Zamanigarmsiri F¹ ; Meshkani R¹

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1. Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Life Sciences Published:2023

Abstract

Aim: The valuable effects of metformin (MET) and morin (MOR) in the improvement of NAFLD have been proposed, nevertheless, their combination impacts were not investigated so far. We determined the therapeutic effects of combined MET and MOR treatment in high-fat diet (HFD)-induced Non-alcoholic fatty liver disease (NAFLD) mice. Methods: C57BL/6 mice were fed on an HFD for 15 weeks. Animals were allotted into various groups and supplemented with MET (230 mg/kg), MOR (100 mg/kg), and MET + MOR (230 mg/kg + 100 mg/kg). Key findings: MET in combination with MOR reduced body and liver weight in HFD-fed mice. A significant decrease in fasting blood glucose and improvement in glucose tolerance was observed in HFD mice treated with MET + MOR. Supplementation with MET + MOR led to a decline in hepatic triglyceride levels and this impact was associated with diminished expression of fatty-acid synthase (FAS) and elevated expression of carnitine palmitoyl transferase 1 (CPT1) and phospho-Acetyl-CoA Carboxylase (p-ACC). Moreover, MET combined with MOR alleviates hepatic inflammation through the polarization of macrophages to the M2 phenotype, decreasing the infiltration of macrophages and lowering the protein level of NF-kB. MET and MOR in combination reduce the size and weight of epididymal white adipose tissue (eWAT), and subcutaneous WAT (sWAT), whereas improves cold tolerance, BAT activity, and mitochondrial biogenesis. Combination therapy results in stimulating brown-like adipocyte (beige) formation in the sWAT of HFD mice. Significance: These results suggest that the combination of MET and MOR has a protective effect on hepatic steatosis, which may use as a candidate therapeutic for the improvement of NAFLD. © 2023

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Reza Meshkani (4)

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Style	Citing Format
MLA	Tehrani SS, et al.. "The Combination of Metformin With Morin Alleviates Hepatic Steatosis Via Modulating Hepatic Lipid Metabolism, Hepatic Inflammation, Brown Adipose Tissue Thermogenesis, and White Adipose Tissue Browning in High-Fat Diet-Fed Mice." Life Sciences, vol. 323, no. , 2023, pp. -.
APA	Tehrani SS, Goodarzi G, Panahi G, Zamanigarmsiri F, Meshkani R (2023). The Combination of Metformin With Morin Alleviates Hepatic Steatosis Via Modulating Hepatic Lipid Metabolism, Hepatic Inflammation, Brown Adipose Tissue Thermogenesis, and White Adipose Tissue Browning in High-Fat Diet-Fed Mice. Life Sciences, 323(), -.
Chicago	Tehrani SS, Goodarzi G, Panahi G, Zamanigarmsiri F, Meshkani R. "The Combination of Metformin With Morin Alleviates Hepatic Steatosis Via Modulating Hepatic Lipid Metabolism, Hepatic Inflammation, Brown Adipose Tissue Thermogenesis, and White Adipose Tissue Browning in High-Fat Diet-Fed Mice." Life Sciences 323, no. (2023): -.
Harvard	Tehrani SS et al. (2023) 'The Combination of Metformin With Morin Alleviates Hepatic Steatosis Via Modulating Hepatic Lipid Metabolism, Hepatic Inflammation, Brown Adipose Tissue Thermogenesis, and White Adipose Tissue Browning in High-Fat Diet-Fed Mice', Life Sciences, 323(), pp. -.
Vancouver	Tehrani SS, Goodarzi G, Panahi G, Zamanigarmsiri F, Meshkani R. The Combination of Metformin With Morin Alleviates Hepatic Steatosis Via Modulating Hepatic Lipid Metabolism, Hepatic Inflammation, Brown Adipose Tissue Thermogenesis, and White Adipose Tissue Browning in High-Fat Diet-Fed Mice. Life Sciences. 2023;323():-.
BibTex	@article{ author = {Tehrani SS and Goodarzi G and Panahi G and Zamanigarmsiri F and Meshkani R}, title = {The Combination of Metformin With Morin Alleviates Hepatic Steatosis Via Modulating Hepatic Lipid Metabolism, Hepatic Inflammation, Brown Adipose Tissue Thermogenesis, and White Adipose Tissue Browning in High-Fat Diet-Fed Mice}, journal = {Life Sciences}, volume = {323}, number = {}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Tehrani SS AU - Goodarzi G AU - Panahi G AU - Zamanigarmsiri F AU - Meshkani R TI - The Combination of Metformin With Morin Alleviates Hepatic Steatosis Via Modulating Hepatic Lipid Metabolism, Hepatic Inflammation, Brown Adipose Tissue Thermogenesis, and White Adipose Tissue Browning in High-Fat Diet-Fed Mice JO - Life Sciences VL - 323 IS - SP - EP - PY - 2023 ER -

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