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Is Probiotic and Synbiotic Supplementation Effective on Immune Cells? a Systematic Review and Meta-Analysis of Clinical Trials Publisher



Kazemi A1 ; Soltani S2 ; Ghorabi S3 ; Nasri F4 ; Babajafari S5 ; Mazloomi SM5
Authors
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Authors Affiliations
  1. 1. Nutrition research center, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Yazd Cardiovascular research center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  3. 3. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetic, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department immunology, School of medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Nutrition research center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran

Source: Food Reviews International Published:2021


Abstract

Effect of probiotics on various parameters of immune system including immune cells count levels has been demonstrated by clinical trials; however, as far as we know, no meta-analysis has been done. The aim of this systematic review and meta-analysis was to evaluate the effect of probiotic/synbiotic on immune cells in health and disease status. We searched PubMed, SCOPUS, and Web of Science. All clinical trials investigated the effects of oral intake of probiotic/synbiotic on the cellular count of white blood cell (WBC), T and B lymphocyte, monocyte, neutrophil, eosinophil, natural killer (NK) cell count and activity, CD4 and CD8 cell, CD4/CD8, T helper (Th)1 and 2, and Th1/Th2 with duration of more than 7 days with concurrent control were included. Analysis of 108 clinical trials indicated a small significant increase in WBC count, T cell percentage, NK cell count and activity, monocyte percentage. No significant effect of probiotic supplementation was seen on the other immune cells. In conclusion, only a small significant effect of probiotic/synbiotic was seen on some of the immunity markers. © 2020 Taylor & Francis.
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