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Main Gut Bacterial Composition Differs Between Patients With Type 1 and Type 2 Diabetes and Non-Diabetic Adults Publisher



Ejtahed HS1, 2 ; Hoseinitavassol Z3 ; Khatami S4 ; Zangeneh M5 ; Behrouzi A3 ; Ahmadi Badi S3 ; Moshiri A6, 7 ; Hasaniranjbar S1 ; Soroush AR1 ; Vaziri F3 ; Fateh A3 ; Ghanei M8 ; Bouzari S9 ; Najarpeerayeh S10 Show All Authors
Authors
  1. Ejtahed HS1, 2
  2. Hoseinitavassol Z3
  3. Khatami S4
  4. Zangeneh M5
  5. Behrouzi A3
  6. Ahmadi Badi S3
  7. Moshiri A6, 7
  8. Hasaniranjbar S1
  9. Soroush AR1
  10. Vaziri F3
  11. Fateh A3
  12. Ghanei M8
  13. Bouzari S9
  14. Najarpeerayeh S10
  15. Siadat SD2, 3
  16. Larijani B2
Show Affiliations
Authors Affiliations
  1. 1. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Mycobacteriology and Pulmonary Research, Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran
  4. 4. Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran
  5. 5. Department of Infectious Diseases, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  6. 6. Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Genoa, Italy
  8. 8. Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
  9. 9. Molecular Biology Department, Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran
  10. 10. Bacteriology Department, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Source: Journal of Diabetes and Metabolic Disorders Published:2020


Abstract

Background: Regarding the role of gut microbial dysbiosis in hyperglycemia, we aimed to compare the main gut bacterial composition among type 1 and type 2 diabetic patients and healthy non-diabetic adults. Methods: A total of 110 adult subjects (49 patients diagnosed with type 2 diabetes, 21 patients diagnosed with type 1 diabetes and 40 healthy persons) were included in this case-control study. The intestinal microbiota composition was investigated by quantitative real-time polymerase chain reaction (qPCR) method targeting bacterial 16S rRNA gene. Comparison between three groups was done using one-way analysis of variance. Results: The participants’ mean age in the type 1 diabetes, type 2 diabetes and control groups was 35.4, 57.2 and 38.0 years, respectively. Higher level of Escherichia, Prevotella and Lactobacillus was observed in both type 1 and type 2 diabetic patients compared with the healthy group (P ˂0.001). In contrast, bacterial load of Bifidobacterium, Roseburia and Bacteroides was higher in healthy control group (P < 0.05). Faecalibacterium was significantly lower in type 1 diabetic patients compared with the other two groups (P ˂0.001). No significant difference was found in Akkermansia level among three groups. Conclusions: Gut microbial alterations have been observed among patients suffering from type 1 and type 2 diabetes mellitus and healthy control adults. Butyrate producing genera including Roseburia and Faecalibacterium decreased while Escherichia, Prevotella and Lactobacillus increased in diabetic patients compared to healthy subjects. Modulating approaches of gut microbiota composition could be helpful in diabetes management. © 2020, Springer Nature Switzerland AG.
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