Role of Proangiogenic Factors in Immunopathogenesis of Multiple Sclerosis: A Systematic Review Pubmed



Hamid KM^{1, 2} ; Mirshafiey A¹ Show Affiliations
Source: Iranian Journal of Allergy# Asthma and Immunology Published:2016

Abstract

Angiogenesis is a complex and balanced process in which new blood vessels form from preexisting ones by sprouting, splitting, growth and remodeling. This phenomenon plays a vital role in many physiological and pathological processes. However, the disturbance in physiological process can play a role in pathogenesis of some chronic inflammatory diseases, including multiple sclerosis (MS) in human and its animal model. Although the relation between abnormal blood vessels and MS lesions was established in previous studies, but the role of pathological angiogenesis remains unclear. In this study, the link between proangiogenic factors and multiple sclerosis pathogenesis was examined by conducting a systematic review. Thus we searched the English medical literature via PubMed, ISI web of knowledge, Medline and virtual health library (VHL) databases. In this review, we describe direct and indirect roles of some proangiogenic factors in MS pathogenesis and report the association of these factors with pathological and inflammatory angiogenesis. © Copyright Winter 2016, Iran J Allergy Asthma Immunol. All rights reserved.