Expression Analysis of Mtor-Associated Lncrnas in Multiple Sclerosis

Expression Analysis of Mtor-Associated Lncrnas in Multiple Sclerosis Publisher Pubmed

Akbari M¹ ; Eshghyar F² ; Gholipour M³ ; Eslami S^{4, 5} ; Hussen BM^{6, 7} ; Taheri M^{8, 9} ; Omrani MD³ ; Ghafourifard S³

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1. Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Department of Medical Biotechnology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
5. Dietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Karaj, Iran
6. Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Kurdistan Region, Erbil, Iraq
7. Center of Research and Strategic Studies, Lebanese French University, Kurdistan Region, Erbil, Iraq
8. Menâ€™s Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
9. Institute of Human Genetics, Jena University Hospital, Jena, Germany

Source: Metabolic Brain Disease Published:2022

Abstract

mTOR has been shown to be involved in the regulation of immune responses and differentiation of immune cells. This protein is a candidate molecule for unraveling the molecular mechanisms of autoimmune disorders such as multiple sclerosis (MS). We designed the current study to assess expression of MTOR, and four associated long non-coding RNAs (lncRNAs), namely SNHG1, SNHG3, SHNG5 and DANCR in the peripheral blood of patients with MS compared with healthy controls. Analysis of real-time PCR results has shown down-regulation of SNHG5 and DANCR in MS patients compared with controls. Sex of study participants had no significant effect on expression of either genes and the interaction of sex and disease on expression levels of all studied genes were insignificant. There was a significant negative correlation between expression levels of MTOR gene and disease duration. No other significant correlations were detected between genes expressions and clinical/demographic data. SNHG5 and DANCR transcript levels had AUC values of 0.88 and 0.68 in separation of patients with MS from healthy controls, respectively. Taken together, our study suggests participation of two mTOR-related lncRNAs, i.e. SNHG5 and DANCR in the pathophysiology of MS. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

2. Upregulation of Mtor, Rps6kb1, and Eif4ebp1 in the Whole Blood Samples of Iranian Patients With Multiple Sclerosis Compared to Healthy Controls, Metabolic Brain Disease (2020)

Style	Citing Format
MLA	Akbari M, et al.. "Expression Analysis of Mtor-Associated Lncrnas in Multiple Sclerosis." Metabolic Brain Disease, vol. 37, no. 6, 2022, pp. 2061-2066.
APA	Akbari M, Eshghyar F, Gholipour M, Eslami S, Hussen BM, Taheri M, Omrani MD, Ghafourifard S (2022). Expression Analysis of Mtor-Associated Lncrnas in Multiple Sclerosis. Metabolic Brain Disease, 37(6), 2061-2066.
Chicago	Akbari M, Eshghyar F, Gholipour M, Eslami S, Hussen BM, Taheri M, Omrani MD, Ghafourifard S. "Expression Analysis of Mtor-Associated Lncrnas in Multiple Sclerosis." Metabolic Brain Disease 37, no. 6 (2022): 2061-2066.
Harvard	Akbari M et al. (2022) 'Expression Analysis of Mtor-Associated Lncrnas in Multiple Sclerosis', Metabolic Brain Disease, 37(6), pp. 2061-2066.
Vancouver	Akbari M, Eshghyar F, Gholipour M, Eslami S, Hussen BM, Taheri M, et al.. Expression Analysis of Mtor-Associated Lncrnas in Multiple Sclerosis. Metabolic Brain Disease. 2022;37(6):2061-2066.
BibTex	@article{ author = {Akbari M and Eshghyar F and Gholipour M and Eslami S and Hussen BM and Taheri M and Omrani MD and Ghafourifard S}, title = {Expression Analysis of Mtor-Associated Lncrnas in Multiple Sclerosis}, journal = {Metabolic Brain Disease}, volume = {37}, number = {6}, pages = {2061-2066}, year = {2022} }
RIS	TY - JOUR AU - Akbari M AU - Eshghyar F AU - Gholipour M AU - Eslami S AU - Hussen BM AU - Taheri M AU - Omrani MD AU - Ghafourifard S TI - Expression Analysis of Mtor-Associated Lncrnas in Multiple Sclerosis JO - Metabolic Brain Disease VL - 37 IS - 6 SP - 2061 EP - 2066 PY - 2022 ER -

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Abstract