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Sodium Dimethyldithiocarbamate Publisher



Abdollahi M1, 2 ; Khaksar MR3
Authors
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Authors Affiliations
  1. 1. Toxicology and Diseases Group (TDG), Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Tehran, Iran
  2. 2. Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  3. 3. Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Encyclopedia of Toxicology# Fourth Edition: Volume 1-9 Published:2023


Abstract

Sodium dimethyldithiocarbamate (SDMC) has been used in a variety of pesticidal applications as insecticide, fungicide, miticide, and microbicide. The dithiocarbamates (DCs) are basically cytotoxic and regarded as broad-spectrum biocides. The DCs are the half amides of dithiocarbamic acid. They have strong metal-binding characteristics and interact with sulfhydryl-containing compounds. They have been used on a large scale in agriculture as pesticide and fungicide, in the rubber industry as vulcanization accelerators, and in research as enzyme inhibitors. SDMC has been extensively used as an analytical reagent for copper and nickel. Studies do not provide evidence that SDMC is a selective or specific reproductive or developmental toxin but it is considered an immunosuppressant in chronic exposure. © 2024 Elsevier Inc. All rights reserved.