Improvement of Cytotoxicity and Necrosis Activity of Ganoderic Acid a Through the Development of Pmbn-A.Her2-Ga As a Targeted Nano System

Improvement of Cytotoxicity and Necrosis Activity of Ganoderic Acid a Through the Development of Pmbn-A.Her2-Ga As a Targeted Nano System Publisher

Motamed Fath P¹ ; Rahimnejad M^{2, 3} ; Moradikalbolandi S⁴ ; Ebrahimi Hosseinzadeh B¹ ; Jamshidnejadtosaramandani T⁵

Show Affiliations

1. Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
2. Biomedical Engineering Institute, School of Medicine, Universite de Montreal, Montreal, Canada
3. Research Centre, Centre Hospitalier de l'Universite de Montreal (CRCHUM), Montreal, Canada
4. Recombinant Proteins Department, Breast Cancer Research Center, Motamed Cancer Institute, Acecr, Tehran, Iran
5. Nano Biotechnology Department, Faculty of Innovative Science and Technology, Razi University, Kermanshah, Iran

Source: RSC Advances Published:2022

Abstract

The targeting nano carriers have been promptly proposed to overcome the current obstacles in conventional chemotherapy approaches for cancer. Currently, PMBN (poly[MPC-co-(BMA)-co-(MEONP)]), is considered as a promising amphiphilic polymer that could be easily targeted and conjugated to hydrophobic substances with low bioavailability. To target breast cancer cells overexpressing human epidermal receptor 2 (HER2) receptors, anti-HER2 monoclonal antibody (A.Her2) was conjugated to PMBN and afterward loaded with ganoderic acid A (GA-A) as an anti-cancer metabolite. The efficacy of conjugation and loading was reasonably favourable. The rod shape of the polymer with a size of approximately 160 ± 30 nm was confirmed. Our results indicated that PMBN-A.Her2-GA is an anionic nanostructure with an appropriate form and capable of being applied in cancer therapy. Subsequently, cytotoxicity analysis revealed an improved anti-proliferative effect of GA-A. © The Royal Society of Chemistry.

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Style	Citing Format
MLA	Motamed Fath P, et al.. "Improvement of Cytotoxicity and Necrosis Activity of Ganoderic Acid a Through the Development of Pmbn-A.Her2-Ga As a Targeted Nano System." RSC Advances, vol. 12, no. 2, 2022, pp. 1228-1237.
APA	Motamed Fath P, Rahimnejad M, Moradikalbolandi S, Ebrahimi Hosseinzadeh B, Jamshidnejadtosaramandani T (2022). Improvement of Cytotoxicity and Necrosis Activity of Ganoderic Acid a Through the Development of Pmbn-A.Her2-Ga As a Targeted Nano System. RSC Advances, 12(2), 1228-1237.
Chicago	Motamed Fath P, Rahimnejad M, Moradikalbolandi S, Ebrahimi Hosseinzadeh B, Jamshidnejadtosaramandani T. "Improvement of Cytotoxicity and Necrosis Activity of Ganoderic Acid a Through the Development of Pmbn-A.Her2-Ga As a Targeted Nano System." RSC Advances 12, no. 2 (2022): 1228-1237.
Harvard	Motamed Fath P et al. (2022) 'Improvement of Cytotoxicity and Necrosis Activity of Ganoderic Acid a Through the Development of Pmbn-A.Her2-Ga As a Targeted Nano System', RSC Advances, 12(2), pp. 1228-1237.
Vancouver	Motamed Fath P, Rahimnejad M, Moradikalbolandi S, Ebrahimi Hosseinzadeh B, Jamshidnejadtosaramandani T. Improvement of Cytotoxicity and Necrosis Activity of Ganoderic Acid a Through the Development of Pmbn-A.Her2-Ga As a Targeted Nano System. RSC Advances. 2022;12(2):1228-1237.
BibTex	@article{ author = {Motamed Fath P and Rahimnejad M and Moradikalbolandi S and Ebrahimi Hosseinzadeh B and Jamshidnejadtosaramandani T}, title = {Improvement of Cytotoxicity and Necrosis Activity of Ganoderic Acid a Through the Development of Pmbn-A.Her2-Ga As a Targeted Nano System}, journal = {RSC Advances}, volume = {12}, number = {2}, pages = {1228-1237}, year = {2022} }
RIS	TY - JOUR AU - Motamed Fath P AU - Rahimnejad M AU - Moradikalbolandi S AU - Ebrahimi Hosseinzadeh B AU - Jamshidnejadtosaramandani T TI - Improvement of Cytotoxicity and Necrosis Activity of Ganoderic Acid a Through the Development of Pmbn-A.Her2-Ga As a Targeted Nano System JO - RSC Advances VL - 12 IS - 2 SP - 1228 EP - 1237 PY - 2022 ER -

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