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Synthesis of Novel Derivatives of Chromenone Bearing an N-Carbamothioyl Moiety As Soybean 15-Lox Inhibitors Publisher



Kaviani R1 ; Saeedi M2, 3 ; Mahdavi M4 ; Nadri H5 ; Moradi A5 ; Shafiee A6 ; Akbarzadeh T3, 7
Authors

Source: Turkish Journal of Chemistry Published:2017


Abstract

Novel derivatives of chromenone bearing an N-carbamothioyl moiety were synthesized and evaluated for their soybean 15-LOX inhibitory activity. Synthesis of the target compounds was started from 7-hydroxy-2H-chromen-2-one. It was reacted with 1-fluoro-2(4)-nitrobenzene to obtain the corresponding nitrophenoxy-chromenone derivative. Reduction of the nitro group was achieved in the presence of Zn/NH4Cl and reaction of the latter compound with in situ prepared benzoyl isothiocyanate led to the formation of the title compounds. All compounds were characterized and tested against soybean 15-LOX. Among them, 4-methyl-N-((4-((2-oxo-2H-chromen-7-yl)oxy)phenyl)carbamothioyl)benzamide (7l) showed the best activity as potent as the reference drug, quercetin. © TUBITAK.
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