Synthesis of Thiazolone Derivatives As Novel Soybean 15-Lox Inhibitors

Synthesis of Thiazolone Derivatives As Novel Soybean 15-Lox Inhibitors Publisher

Mahdavi M¹ ; Saeedi M^{2, 3} ; Nadri H⁴ ; Eghtedari M⁵ ; Gholizadeh S¹ ; Hariri R³ ; Akbarzadeh T^{3, 6}

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1. School of Pharmacy, International Campus (TUMS-IC), Tehran University of Medical Sciences, Tehran, Iran
2. Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Medicinal Chemistry, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
5. Faculty of Chemistry, University of Mazandaran, Babolsar, Iran
6. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box: 14155-6451, Tehran, Iran

Source: Letters in Organic Chemistry Published:2017

Abstract

Background: Thiazole derivatives are known as important sulfur containing heterocycles which are present in a wide range of biologically active natural products. Methods: A series of thiazolone derivatives were synthesized and evaluated for their soybean 15-LOX inhibitory activity. The title compounds were prepared by the reaction of 2-arylthiazol-4(5H)-ones and different aromatic aldehydes. All compounds were characterized and evaluated against soybean 15-LOX. Results: Among the synthesized thiazolone derivatives, 5-(4-methoxybenzylidene)-2-((2-methoxyphenyl) amino)thiazol-4(5H)-one (3l) was found to be the most active compound comparing with quercetin as the reference drug. Conclusion: It seems that prepared thiazolones having methoxy groups both on aryl and aminoaryl moieties can be considered for further drug discovery research. © 2017 Bentham Science Publishers.

2. Quinoline-Based Imidazole-Fused Heterocycles As New Inhibitors of 15-Lipoxygenase, Journal of Enzyme Inhibition and Medicinal Chemistry (2016)

3. Synthesis of Novel 1,2,3-Triazole-Dihydro[3,2-C[Chromenones As Acetylcholinesterase Inhibitors, Synthetic Communications (2015)

4. Novel Indole-Isoxazole Hybrids: Synthesis and in Vitro Anti-Cholinesterase Activity, Letters in Drug Design and Discovery (2017)

5. New Benzyl Pyridinium Derivatives Bearing 2,4-Dioxochroman Moiety As Potent Agents for Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Docking Study, Bioorganic Chemistry (2019)

6. Hetero-Annulated Coumarins As New Ache/Buche Inhibitors: Synthesis and Biological Evaluation, Medicinal Chemistry Research (2016)

7. Synthesis and Evaluation of Coumarin-Resveratrol Hybrids As 15-Lipoxygenaze Inhibitors, Synthetic Communications (2015)

8. Novel Tacrine-1,2,3-Triazole Hybrids: In Vitro, in Vivo Biological Evaluation and Docking Study of Cholinesterase Inhibitors, European Journal of Medicinal Chemistry (2017)

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Mohammad Mahdavi (8)

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Style	Citing Format
MLA	Mahdavi M, et al.. "Synthesis of Thiazolone Derivatives As Novel Soybean 15-Lox Inhibitors." Letters in Organic Chemistry, vol. 14, no. 3, 2017, pp. 186-191.
APA	Mahdavi M, Saeedi M, Nadri H, Eghtedari M, Gholizadeh S, Hariri R, Akbarzadeh T (2017). Synthesis of Thiazolone Derivatives As Novel Soybean 15-Lox Inhibitors. Letters in Organic Chemistry, 14(3), 186-191.
Chicago	Mahdavi M, Saeedi M, Nadri H, Eghtedari M, Gholizadeh S, Hariri R, Akbarzadeh T. "Synthesis of Thiazolone Derivatives As Novel Soybean 15-Lox Inhibitors." Letters in Organic Chemistry 14, no. 3 (2017): 186-191.
Harvard	Mahdavi M et al. (2017) 'Synthesis of Thiazolone Derivatives As Novel Soybean 15-Lox Inhibitors', Letters in Organic Chemistry, 14(3), pp. 186-191.
Vancouver	Mahdavi M, Saeedi M, Nadri H, Eghtedari M, Gholizadeh S, Hariri R, et al.. Synthesis of Thiazolone Derivatives As Novel Soybean 15-Lox Inhibitors. Letters in Organic Chemistry. 2017;14(3):186-191.
BibTex	@article{ author = {Mahdavi M and Saeedi M and Nadri H and Eghtedari M and Gholizadeh S and Hariri R and Akbarzadeh T}, title = {Synthesis of Thiazolone Derivatives As Novel Soybean 15-Lox Inhibitors}, journal = {Letters in Organic Chemistry}, volume = {14}, number = {3}, pages = {186-191}, year = {2017} }
RIS	TY - JOUR AU - Mahdavi M AU - Saeedi M AU - Nadri H AU - Eghtedari M AU - Gholizadeh S AU - Hariri R AU - Akbarzadeh T TI - Synthesis of Thiazolone Derivatives As Novel Soybean 15-Lox Inhibitors JO - Letters in Organic Chemistry VL - 14 IS - 3 SP - 186 EP - 191 PY - 2017 ER -

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