Synthesis of Thiazolone Derivatives As Novel Soybean 15-Lox Inhibitors

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Synthesis of Thiazolone Derivatives As Novel Soybean 15-Lox Inhibitors Publisher

Mahdavi M¹ ; Saeedi M^{2, 3} ; Nadri H⁴ ; Eghtedari M⁵ ; Gholizadeh S¹ ; Hariri R³ ; Akbarzadeh T^{3, 6}

Source: Letters in Organic Chemistry Published:2017

Abstract

Background: Thiazole derivatives are known as important sulfur containing heterocycles which are present in a wide range of biologically active natural products. Methods: A series of thiazolone derivatives were synthesized and evaluated for their soybean 15-LOX inhibitory activity. The title compounds were prepared by the reaction of 2-arylthiazol-4(5H)-ones and different aromatic aldehydes. All compounds were characterized and evaluated against soybean 15-LOX. Results: Among the synthesized thiazolone derivatives, 5-(4-methoxybenzylidene)-2-((2-methoxyphenyl) amino)thiazol-4(5H)-one (3l) was found to be the most active compound comparing with quercetin as the reference drug. Conclusion: It seems that prepared thiazolones having methoxy groups both on aryl and aminoaryl moieties can be considered for further drug discovery research. © 2017 Bentham Science Publishers.

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Style	Citing Format
MLA	Mahdavi M, et al.. "Synthesis of Thiazolone Derivatives As Novel Soybean 15-Lox Inhibitors." Letters in Organic Chemistry, vol. 14, no. 3, 2017, pp. 186-191.
APA	Mahdavi M, Saeedi M, Nadri H, Eghtedari M, Gholizadeh S, Hariri R, Akbarzadeh T (2017). Synthesis of Thiazolone Derivatives As Novel Soybean 15-Lox Inhibitors. Letters in Organic Chemistry, 14(3), 186-191.
Chicago	Mahdavi M, Saeedi M, Nadri H, Eghtedari M, Gholizadeh S, Hariri R, Akbarzadeh T. "Synthesis of Thiazolone Derivatives As Novel Soybean 15-Lox Inhibitors." Letters in Organic Chemistry 14, no. 3 (2017): 186-191.
Harvard	Mahdavi M et al. (2017) 'Synthesis of Thiazolone Derivatives As Novel Soybean 15-Lox Inhibitors', Letters in Organic Chemistry, 14(3), pp. 186-191.
Vancouver	Mahdavi M, Saeedi M, Nadri H, Eghtedari M, Gholizadeh S, Hariri R, et al.. Synthesis of Thiazolone Derivatives As Novel Soybean 15-Lox Inhibitors. Letters in Organic Chemistry. 2017;14(3):186-191.
BibTex	@article{ author = {Mahdavi M and Saeedi M and Nadri H and Eghtedari M and Gholizadeh S and Hariri R and Akbarzadeh T}, title = {Synthesis of Thiazolone Derivatives As Novel Soybean 15-Lox Inhibitors}, journal = {Letters in Organic Chemistry}, volume = {14}, number = {3}, pages = {186-191}, year = {2017} }
RIS	TY - JOUR AU - Mahdavi M AU - Saeedi M AU - Nadri H AU - Eghtedari M AU - Gholizadeh S AU - Hariri R AU - Akbarzadeh T TI - Synthesis of Thiazolone Derivatives As Novel Soybean 15-Lox Inhibitors JO - Letters in Organic Chemistry VL - 14 IS - 3 SP - 186 EP - 191 PY - 2017 ER -

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