Does Folic Acid Supplementation Have a Positive Effect on Improving Memory? a Systematic Review and Meta-Analysis of Randomized Controlled Trials

Does Folic Acid Supplementation Have a Positive Effect on Improving Memory? a Systematic Review and Meta-Analysis of Randomized Controlled Trials Publisher

Akhgarjand C¹ ; Ebrahimi Mousavi S¹ ; Kalantar Z² ; Bagheri A³ ; Imani H¹ ; Rezvani H⁴ ; Ghorbi MD⁵ ; Vahabi Z^{6, 7}

Show Affiliations

1. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Cellular and Molecular Nutrition, School of Nutrition Science and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
4. Hemato-Oncology Ward, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5. Hemato-Oncology Ward, Imam Hossein Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran
6. Cognitive Neurology and Neuropsychiatry Division, Department of Psychiatry, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran
7. Department of Geriatric, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Frontiers in Aging Neuroscience Published:2022

Abstract

Introduction: The results of randomized controlled trials (RCTs) on the effect of folic acid supplementation on memory status due to various heterogeneity, dosage, duration, and cognitive function assessments were inconclusive. Therefore, we have performed a systematic review and meta-analysis to investigate the effect of folic acid supplementation on memory in RCTs. Method: Comprehensive computerized systematic searches were conducted throughout Scopus, PubMed/Medline, and Google Scholar from inception until February 2022 to investigate the effect of folic acid supplementation memory levels in RCTs. The standardized mean difference (SMD) and 95% confidence interval (CIs) were used to estimate the overall effect size using random-effects meta-analyses. Results: The overall results of nine trials with 641 participants, revealed that folic acid supplementation did not significantly change memory score compared to placebo (SMD: 0.12; 95% CI: −0.17, 0.40, p = 0.418; I2 = 62.6%). However, subgroup analyses showed that supplementation with folic acid had favorable effects on memory levels considering the following conditions: (1) doses lower than 1 mg/day, (2) treatment lasting more than 6 months, (3) conducted in eastern countries, and (4) in participants equal to or older than 70 years old. The dose-response analysis suggested a significant favorable effect on memory status at doses of 6–11 mg/d and a significant decline at doses of 17–20 mg/d. Discussion: Although we did not find a significant effect of folic acid supplementation on memory, there were some suggestions of beneficial effects in the subgroup analyses. Copyright © 2022 Akhgarjand, Ebrahimi Mousavi, Kalantar, Bagheri, Imani, Rezvani, Ghorbi and Vahabi.

Related Docs

View other Related Docs

1. Mediterranean Diet for Active and Healthy Aging, Nutrients and Nutraceuticals for Active and Healthy Ageing (2020)

2. The Effects of Folic Acid Supplementation on Pro-Inflammatory Mediators: A Systematic Review and Dose–Response Meta‐Analysis of Randomized Controlled Trials, Clinical Therapeutics (2021)

3. Early Diagnosis of Alzheimer’S Disease With Blood Test; Tempting But Challenging, International Journal of Molecular and Cellular Medicine (2023)

4. Thyroid Hormone Levels in Alzheimer Disease: A Systematic Review and Meta-Analysis, Endocrine (2023)

5. Effect of Evening Primrose Oil Supplementation on Lipid Profile: A Systematic Review and Meta-Analysis of Randomized Clinical Trials, Phytotherapy Research (2020)

6. Effect of Coenzyme Q10 Supplementation on Clinical Features of Migraine: A Systematic Review and Dose–Response Meta-Analysis of Randomized Controlled Trials, Nutritional Neuroscience (2020)

7. Trace Elements in Schizophrenia: A Systematic Review and Meta-Analysis of 39 Studies (N=5151 Participants), Nutrition Reviews (2020)

8. Does Ashwagandha Supplementation Have a Beneficial Effect on the Management of Anxiety and Stress? a Systematic Review and Meta-Analysis of Randomized Controlled Trials, Phytotherapy Research (2022)

Experts (# of related papers)

View all Related Experts

Sakineh Shab-Bidar (13)

Hamed Mohammadi (11)

Style	Citing Format
MLA	Akhgarjand C, et al.. "Does Folic Acid Supplementation Have a Positive Effect on Improving Memory? a Systematic Review and Meta-Analysis of Randomized Controlled Trials." Frontiers in Aging Neuroscience, vol. 14, no. , 2022, pp. -.
APA	Akhgarjand C, Ebrahimi Mousavi S, Kalantar Z, Bagheri A, Imani H, Rezvani H, Ghorbi MD, Vahabi Z (2022). Does Folic Acid Supplementation Have a Positive Effect on Improving Memory? a Systematic Review and Meta-Analysis of Randomized Controlled Trials. Frontiers in Aging Neuroscience, 14(), -.
Chicago	Akhgarjand C, Ebrahimi Mousavi S, Kalantar Z, Bagheri A, Imani H, Rezvani H, Ghorbi MD, Vahabi Z. "Does Folic Acid Supplementation Have a Positive Effect on Improving Memory? a Systematic Review and Meta-Analysis of Randomized Controlled Trials." Frontiers in Aging Neuroscience 14, no. (2022): -.
Harvard	Akhgarjand C et al. (2022) 'Does Folic Acid Supplementation Have a Positive Effect on Improving Memory? a Systematic Review and Meta-Analysis of Randomized Controlled Trials', Frontiers in Aging Neuroscience, 14(), pp. -.
Vancouver	Akhgarjand C, Ebrahimi Mousavi S, Kalantar Z, Bagheri A, Imani H, Rezvani H, et al.. Does Folic Acid Supplementation Have a Positive Effect on Improving Memory? a Systematic Review and Meta-Analysis of Randomized Controlled Trials. Frontiers in Aging Neuroscience. 2022;14():-.
BibTex	@article{ author = {Akhgarjand C and Ebrahimi Mousavi S and Kalantar Z and Bagheri A and Imani H and Rezvani H and Ghorbi MD and Vahabi Z}, title = {Does Folic Acid Supplementation Have a Positive Effect on Improving Memory? a Systematic Review and Meta-Analysis of Randomized Controlled Trials}, journal = {Frontiers in Aging Neuroscience}, volume = {14}, number = {}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Akhgarjand C AU - Ebrahimi Mousavi S AU - Kalantar Z AU - Bagheri A AU - Imani H AU - Rezvani H AU - Ghorbi MD AU - Vahabi Z TI - Does Folic Acid Supplementation Have a Positive Effect on Improving Memory? a Systematic Review and Meta-Analysis of Randomized Controlled Trials JO - Frontiers in Aging Neuroscience VL - 14 IS - SP - EP - PY - 2022 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract