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Association of Transient Global Amnesia (Tga) With Dietary Intake of Vitamin B12 Publisher Pubmed



Shalmani SHM1 ; Mahamoudi Z2 ; Nooriani N3 ; Saeedirad Z4 ; Ardekanizadeh NH5 ; Tavakoli A6 ; Shekari S2 ; Mirshafaei MA7 ; Mele MM8 ; Mirzaee P9 ; Gholamalizadeh M10 ; Bahmani P11 ; Khoshdooz S1 ; Doaei S10, 12
Authors
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Authors Affiliations
  1. 1. Guilan University of Medical Sciences, Rasht, Iran
  2. 2. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran
  3. 3. Nutrition and Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Torbat Jam Faculty of Medical Sciences, Torbat Jam, Iran
  6. 6. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Physical Education and Sport Sciences, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran
  8. 8. Department of Nutrition, School of Public Health, International Campus, Tabriz University of Medical Sciences, Tabriz, Iran
  9. 9. Department of Medicine, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
  10. 10. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  11. 11. Department of Community Nutrition, School of Nutrition and Food Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  12. 12. Reproductive Health Research Center, Department of Obstetrics and Gynecology, School of Medicine, Al-Zahra Hospital, Guilan University of Medical Sciences, Rasht, Iran

Source: Archives of Clinical Neuropsychology Published:2025


Abstract

Background: Transient global amnesia (TGA), which is described as short-term amnesia, may be influenced by some dietary components involved in brain function. The aim of the present study was to assess the connection between TGA and dietary intake of vitamin B12. Methods: This cross-sectional study was conducted on 258 people with TGA and 520 people without TGA in Sabzevar, Iran. All participants were screened for TGA (ICD-10 code: G45.4). A validated Food Frequency Questionnaire (FFQ) was utilized to estimate the dietary intake of vitamin B12. Different models of logistic regression were used to determine the association between TGA and dietary intake of vitamin B12 after adjusting the confounders. Results: There was an inverse association between the risk of TGA and the intake of vitamin B12 (OR = 0.94, CI 95%: 0.89-0.99, p =. 02, effect size: -0.04). The result did not change after adjustment for age, gender, education, job, and marital status (OR = 0.93, CI 95%: 0.88-0.98, p =. 01, effect size: -0.03). The result remained significant after additional adjustments for body mass index (BMI) and physical activity (OR = 0.94, CI 95%: 0.89-0.99, p =. 03, effect size: -0.04), and after further adjustments for the underlying diseases, including diabetes, hypertension, and stroke (OR = 0.86, CI 95%: 0.81-0.92, p <. 01, effect size: -0.10). Conclusion: Vitamin B12 deficiency may increase the risk of TGA and should be considered as a potential concern for people at risk for TGA. Further studies are needed to validate these findings and to discover the underlying mechanisms of the effects of vitamin B12 on TGA. © 2024 The Author(s). Published by Oxford University Press. All rights reserved.
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