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The Safety and Efficacy of Neva Mechanical Thrombectomy Device in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis Publisher Pubmed



Habibi MA1 ; Mirjnani MS2 ; Kargarsoleimanabad S3 ; Akbari Javar MT4 ; Diyanati M4 ; Ahmadvand MH5 ; Berglar IK6 ; Dmytriw AA6
Authors
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Authors Affiliations
  1. 1. Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iraq
  2. 2. Student Research Committee, Qom University of Medical Sciences, Qom, Iraq
  3. 3. Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iraq
  4. 4. Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  5. 5. Faculty of Medicine, Tehran University of Medical Science, Tehran, Iraq
  6. 6. Neuroendovascular Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States

Source: Journal of Clinical Neuroscience Published:2024


Abstract

Background: Recent favorable cohort studies on endovascular therapy for ischemic stroke have predominantly utilized NeVa thrombectomy (NeVaTM) stent retrievers. We carried out a systematic review and meta-analysis to investigate the efficacy and safety of this second-generation stent retriever in acute ischemic stroke patients. Method: We conducted the study according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The electronic databases of PubMed, Embase, and Scopus were searched until 26 November 2023 and was updated on August 1, 2024. Results: This meta-analysis systematically investigated 11 studies with a total of 805 patients suffering from ischemic stroke. The mean age of participants across the studies ranged from 65 to 77 years with a male preponderance of 50.16 %. While ten studies reported on the etiology of strokes, some studies reported the risk factors such as hypertension, dyslipidemia, diabetes, history of coronary artery disease, and previous stroke. The results of our study indicate that the all-hemorrhagic complications rate was 0.32 (95 %CI: 0.18–0.45), while the complete arterial recanalization rate was 0.76 [95 %CI: 0.49–1.04]. The overall recanalization rate was found to be 0.97 [95 %CI: 0.94–1.00]. Moreover, the postoperative hemorrhage rate was 0.28 [95 %CI: 0.14–0.41], while the repeated re-thrombosis rate was 0.01 [95 %CI: −0.01–0.03]. Lastly, the vasospasm rate was calculated to be 0.09 [95 %CI: −0.03–0.21]. Conclusion: NeVa™ is a safe option capable of achieving a high rate of recanalization and functional independence. Abbreviations: PRISMA, Preferred Reporting Items for Systematic Reviews and Meta-Analyses; PROSPERO, International Prospective Register of Systematic Reviews; NeVa™, NeVa Thrombectomy; ICH, Intracranial Hemorrhage; mTICI, modified Thrombolysis in Cerebral Infarction; mRS, modified Rankin Scale; ACA, Anterior Cerebral Artery; MCA, Middle Cerebral Artery; PCA, Posterior Cerebral Artery; ICA, Internal Carotid Artery; NIHSS, National Institutes of Health Stroke Scale. © 2024 Elsevier Ltd
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