The Emerging Crosstalk Between Atherosclerosis-Related Micrornas and Bermuda Triangle of Foam Cells: Cholesterol Influx, Trafficking, and Efflux

The Emerging Crosstalk Between Atherosclerosis-Related Micrornas and Bermuda Triangle of Foam Cells: Cholesterol Influx, Trafficking, and Efflux Publisher Pubmed

Achmad H¹ ; Almajidi YQ² ; Adel H³ ; Obaid RF⁴ ; Romeroparra RM⁵ ; Kadhum WR⁶ ; Almulla AF⁷ ; Alhachami FR⁸ ; Gabr GA^{9, 10} ; Mustafa YF¹¹ ; Mahmoudi R¹² ; Hosseinifard S^{12, 13}

Show Affiliations

1. Department of Pediatric Dentistry, Faculty of Dentistry, Hasanuddin University, Indonesia
2. Department of Pharmacy, Baghdad College of Medical Sciences, Baghdad, Iraq
3. Al-Farahidi University, College of Dentistry, Baghdad, Iraq
4. Department of Biomedical Engineering, Al-Mustaqbal University College, Babylon, Iraq
5. Universidad Continental, Lima, Peru
6. Department of Pharmacy, Kut University College, Wasit, Kut, 52001, Iraq
7. Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq
8. Radiology Department, College of Health and Medical Technology, Al-Ayen University, Thi-Qar, Iraq
9. Department of Pharmacology and Toxicology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia
10. Agricultural Genetic Engineering Research Institute (AGERI), Agricultural Research Center, Giza, Egypt
11. Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, 41001, Iraq
12. Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
13. Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Cellular Signalling Published:2023

Abstract

In atherosclerosis, the gradual buildup of lipid particles into the sub-endothelium of damaged arteries leads to numerous lipid alterations. The absorption of these modified lipids by monocyte-derived macrophages in the arterial wall leads to cholesterol accumulation and increases the likelihood of foam cell formation and fatty streak, which is an early characteristic of atherosclerosis. Foam cell formation is related to an imbalance in cholesterol influx, trafficking, and efflux. The formation of foam cells is heavily regulated by various mechanisms, among them, the role of epigenetic factors like microRNA alteration in the formation of foam cells has been well studied. Recent studies have focused on the potential interplay between microRNAs and foam cell formation in the pathogenesis of atherosclerosis; nevertheless, there is significant space to progress in this attractive field. This review has focused to examine the underlying processes of foam cell formation and microRNA crosstalk to provide a deep insight into therapeutic implications in atherosclerosis. © 2023

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Style	Citing Format
MLA	Achmad H, et al.. "The Emerging Crosstalk Between Atherosclerosis-Related Micrornas and Bermuda Triangle of Foam Cells: Cholesterol Influx, Trafficking, and Efflux." Cellular Signalling, vol. 106, no. , 2023, pp. -.
APA	Achmad H, Almajidi YQ, Adel H, Obaid RF, Romeroparra RM, Kadhum WR, Almulla AF, Alhachami FR, Gabr GA, Mustafa YF, Mahmoudi R, Hosseinifard S (2023). The Emerging Crosstalk Between Atherosclerosis-Related Micrornas and Bermuda Triangle of Foam Cells: Cholesterol Influx, Trafficking, and Efflux. Cellular Signalling, 106(), -.
Chicago	Achmad H, Almajidi YQ, Adel H, Obaid RF, Romeroparra RM, Kadhum WR, Almulla AF, et al.. "The Emerging Crosstalk Between Atherosclerosis-Related Micrornas and Bermuda Triangle of Foam Cells: Cholesterol Influx, Trafficking, and Efflux." Cellular Signalling 106, no. (2023): -.
Harvard	Achmad H et al. (2023) 'The Emerging Crosstalk Between Atherosclerosis-Related Micrornas and Bermuda Triangle of Foam Cells: Cholesterol Influx, Trafficking, and Efflux', Cellular Signalling, 106(), pp. -.
Vancouver	Achmad H, Almajidi YQ, Adel H, Obaid RF, Romeroparra RM, Kadhum WR, et al.. The Emerging Crosstalk Between Atherosclerosis-Related Micrornas and Bermuda Triangle of Foam Cells: Cholesterol Influx, Trafficking, and Efflux. Cellular Signalling. 2023;106():-.
BibTex	@article{ author = {Achmad H and Almajidi YQ and Adel H and Obaid RF and Romeroparra RM and Kadhum WR and Almulla AF and Alhachami FR and Gabr GA and Mustafa YF and Mahmoudi R and Hosseinifard S}, title = {The Emerging Crosstalk Between Atherosclerosis-Related Micrornas and Bermuda Triangle of Foam Cells: Cholesterol Influx, Trafficking, and Efflux}, journal = {Cellular Signalling}, volume = {106}, number = {}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Achmad H AU - Almajidi YQ AU - Adel H AU - Obaid RF AU - Romeroparra RM AU - Kadhum WR AU - Almulla AF AU - Alhachami FR AU - Gabr GA AU - Mustafa YF AU - Mahmoudi R AU - Hosseinifard S TI - The Emerging Crosstalk Between Atherosclerosis-Related Micrornas and Bermuda Triangle of Foam Cells: Cholesterol Influx, Trafficking, and Efflux JO - Cellular Signalling VL - 106 IS - SP - EP - PY - 2023 ER -

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