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The Role of Magnesium Sulfate in the Intensive Care Unit Publisher



Panahi Y1, 2 ; Mojtahedzadeh M2, 3 ; Najafi A4 ; Ghaini MR5 ; Abdollahi M6 ; Sharifzadeh M6 ; Ahmadi A4 ; Rajaee SM1 ; Sahebkar A7
Authors
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Authors Affiliations
  1. 1. Clinical Pharmacy Department, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran
  2. 2. Clinical Pharmacy Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Anesthesiology and Critical Care Medicine, Faculty of Medicine, Sina Hospital Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Neurosurgery and Neurology, Sina Hospital, Tehran University, Iran
  6. 6. Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Source: EXCLI Journal Published:2017


Abstract

Magnesium (Mg) has been developed as a drug with various clinical uses. Mg is a key cation in physiological processes, and the homeostasis of this cation is crucial for the normal function of body organs. Magnesium sulfate (MgSO4) is a mineral pharmaceutical preparation of magnesium that is used as a neuroprotective agent. One rationale for the frequent use of MgSO4 in critical care is the high incidence of hypomagnesaemia in intensive care unit (ICU) patients. Correction of hypomagnesaemia along with the neuroprotective properties of MgSO4 has generated a wide application for MgSO4 in ICU. © 2017, Leibniz Research Centre for Working Environment and Human Factors. All rights reserved.