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Neuroprotective Agents in the Intensive Care Unit Publisher



Panahi Y1, 2 ; Mojtahedzadeh M2, 3 ; Najafi A4 ; Rajaee SM4 ; Torkaman M5 ; Sahebkar A6, 7, 8
Authors
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Authors Affiliations
  1. 1. Clinical Pharmacy Department, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran
  2. 2. Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Anesthesiology and Critical Care Medicine, Faculty of Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Gastrointestinal Pharmacology Interest Group(GPIG), Universal Scientific Education and Research Network(USERN), Tehran, Iran
  5. 5. Department of Pediatrics, School of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
  6. 6. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Journal of Pharmacopuncture Published:2018


Abstract

Neuroprotection or prevention of neuronal loss is a complicated molecular process that is mediated by various cellular pathways. Use of different pharmacological agents as neuroprotectants has been reported especially in the last decades. These neuroprotective agents act through inhibition of inflammatory processes and apoptosis, attenuation of oxidative stress and reduction of free radicals. Control of this injurious molecular process is essential to the reduction of neuronal injuries and is associated with improved functional outcomes and recovery of the patients admitted to the intensive care unit. This study reviews neuroprotective agents and their mechanisms of action against central nervous system damages. © 2018 Korean Pharmacopuncture Institute.
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