Effect of Curcumin on C-Reactive Protein As a Biomarker of Systemic Inflammation: An Updated Meta-Analysis of Randomized Controlled Trials Publisher Pubmed



Gorabi AM¹ ; Abbasifard M^{2, 3} ; Imani D⁴ ; Aslani S⁵ ; Razi B⁶ ; Alizadeh S⁷ ; Bagherihosseinabadi Z^{3, 8} ; Sathyapalan T⁹ ; Sahebkar A^{10, 11, 12, 13} Show Affiliations
Source: Phytotherapy Research Published:2022

Abstract

It has been suggested that curcumin is a potential agent for lowering the levels of C-reactive protein (CRP) and high-sensitivity CRP (hs-CRP), as markers of inflammation. In the current meta-analysis, we attempted to clarify the efficacy of curcumin supplementation in lowering the concentrations of CRP and hs-CRP in patients with autoinflammatory conditions. Nine studies were found evaluating the effect of curcumin on CRP levels, while 23 studies were identified for hs-CRP. CRP concentration was decreased significantly compared to the placebo (WMD = -3.67 mg/L, 95% CI = −6.96 to −0.38, p = 0.02). There was a significant effect of curcumin at dose ≤1,000 mg/day on the CRP concentration. CRP concentration significantly decreased after >10-week intervention compared with placebo.hs-CRP concentration in the intervention group was significantly lower than that of placebo group. A significant effect of curcumin consumption was detected on the serum level of hs-CRP in studies with prescribing ≤1,000 mg/day, and those with ≤10-week duration of intervention. Curcumin consumption resulted in a reduction of hs-CRP in a non-linear fashion with stronger effects with less than 2000 mg curcumin per day. Curcumin seems to be beneficial in decreasing the hs-CRP and CRP levels in proinflammatory settings. © 2021 John Wiley & Sons Ltd.