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Effects of Curcumin Supplementation on Inflammatory Biomarkers in Patients With Rheumatoid Arthritis and Ulcerative Colitis: A Systematic Review and Meta-Analysis Publisher Pubmed



Ebrahimzadeh A1 ; Abbasi F2 ; Ebrahimzadeh A1 ; Jibril AT4 ; Milajerdi A1, 5
Authors
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Authors Affiliations
  1. 1. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
  2. 2. Department of Sports Injuries, Faculty of Physical Education and Sports Sciences, Allameh Tabataba'i University, Tehran, Iran
  3. 3. Homaijan Health Care Center, Deputy of Health, Shiraz University of Medical Sciences, Shiraz, Iran
  4. 4. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Iran
  5. 5. Department of Health, Science and Research Branch, AJA University of Medical Sciences, Tehran, Iran

Source: Complementary Therapies in Medicine Published:2021


Abstract

Background: Although previous studies have examined the impact of curcumin supplementation on cytokine levels in patients with autoimmune disorders, we were unable to find a systematic review of the effect of curcumin supplementation on inflammatory biomarkers such as CRP and ESR in patients with rheumatoid arthritis or ulcerative colitis; therefore we conducted this systematic review and meta-analysis. Methods: Relevant studies published from inception to December 2020 were systematically searched through the PubMed, SCOPUS, and google scholar databases. We conducted our systematic review and meta-analysis according to the 2020 PRISMA guidelines. The quality of the papers were assessed by using the Cochrane Collaboration's risk of bias tool. Included studies were randomized clinical trials on the effects of supplementation with curcumin or its derivative on inflammatory factors in patients with rheumatoid arthritis and ulcerative colitis. Pooled effect sizes were calculated using a random-effects model and reported as the weighted mean difference (WMD) and 95 % CI. Results: In all, six studies met the inclusion criteria for this study. Curcumin supplementation in doses of 250−1500 mg/day over 8–12 weeks was observed to be associated with decreases in CRP and ESR in adult patients with rheumatoid arthritis and ulcerative colitis in comparison with the control group (WMD: −0.42; 95 % CI: −0.59, −0.26, I2 = 94.3 %; WMD: −55.96; 95 % CI: −93.74, −18.17, I2 = 99.7 %, respectively). Significant findings were also observed based on subgroup analyses by the study sample size, duration, participants’ age, curcumin dosage, and type of disease. Conclusions: Curcumin supplementation was associated with significant reductions in levels of CRP and ESR in patients with rheumatoid arthritis and ulcerative colitis. Earlier studies reported curcumin as a safe complementary therapy for several diseases. However, a handful of studies were found on the effect of curcumin on autoimmune diseases despite our comprehensive search. Further studies are therefore warranted in this area. © 2021
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