Coordinated Mof-2D Nanosheet Hybrids: Bridging Structural Design and Multifunctional Biosensing/Theragnostic Applications Publisher



Naghib SM ; Khorasani MA ; Pebdeni AB ; Sharifianjazi F ; Tavamaishvili K
Source: TrAC - Trends in Analytical Chemistry Published:2026

Abstract

Coordinated metal-organic framework (MOF)-2D nanosheet hybrids represent a rapidly advancing class of multifunctional materials that bridge precise structural design with versatile biosensing and theranostic applications. This review comprehensively examines the synthesis strategies, coordination chemistry and unique physicochemical properties of MOF-2D nanosheets, emphasizing their role in enhancing sensitivity, selectivity and catalytic activity. We explore their stimuli-responsive behaviors enabling smart therapeutic activation, including controlled drug delivery, advanced imaging and photothermal therapy. The synergistic interplay between coordination sites and 2D nanosheet morphology is highlighted as a key factor driving superior biosensing performance and therapeutic efficacy. Additionally, we discuss current challenges related to stability, scalability and clinical translation, alongside emerging trends and next-generation designs poised to propel this field forward. This study offers crucial insights into the rational engineering of MOF-2D nanosheet hybrids, underscoring their potential as transformative platforms in precision medicine and multifunctional diagnostics. © 2026 Elsevier B.V.