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Current Trends in Stimuli-Responsive Nanotheranostics Based on Metal–Organic Frameworks for Cancer Therapy Publisher



Oroojalian F1, 2 ; Karimzadeh S3 ; Javanbakht S4 ; Hejazi M5 ; Baradaran B6 ; Webster TJ7 ; Mokhtarzadeh A6 ; Varma RS8 ; Kesharwani P9 ; Sahebkar A10, 11, 12, 13
Authors
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Authors Affiliations
  1. 1. Department of Advanced Technologies, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
  2. 2. Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
  3. 3. Faculty of Chemical Engineering, Sahand University of Technology, Tabriz, Iran
  4. 4. Faculty of Chemistry, University of Tabriz, Tabriz, Iran
  5. 5. Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. CBCMT, Vellore Institute of Technology, Vellore, 632014, India
  8. 8. Regional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacky University in Olomouc, Olomouc, Czech Republic
  9. 9. Department of Pharmaceutics, School of Pharmaceutical Education & Research, Jamia Hamdard, Hamdard Nagar, New Delhi, 110062, India
  10. 10. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  11. 11. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  12. 12. School of Medicine, The University of Western Australia, Perth, Australia
  13. 13. Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Materials Today Published:2022


Abstract

In the biomedical field, stimuli-responsive systems comprising smart nanoplatforms based on metal–organic frameworks (MOFs) have garnered immense attention in view of their high surface area, biocompatibility, facile synthesis, tunable structural features, adjustable pore size, and highly versatile composition. Interestingly, stimuli-responsive MOFs are excellent nanoplatforms for biomedical applications as they are designed to specifically change their properties upon interior stimuli in target tissues (e.g., pH and redox reaction triggering agents) or exposure to exterior stimuli like temperature, various wavelengths of light and magnetic fields. Compared to other single-imaging techniques either alone or in combination with each other, synergistic therapy based on multimodal imaging-guided strategies deliver high diagnostic accuracy, as well as superior therapeutic efficiency. In order to fully comprehend the field of stimuli-responsive MOFs, herein, the basic mechanistic chemistry of stimuli-responsive MOFs along with the latest progress in the development of cell imaging and theranostic nanoplatforms for biomedical imaging, phototherapy and cancer chemotherapy is elaborated. © 2022 Elsevier Ltd
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